Redox Control of the Cell Cycle in Health and Disease

Ehab H Sarsour; Maneesh G Kumar; Leena Chaudhuri; Amanda L Kalen; Prabhat C Goswami

doi:10.1089/ars.2009.2513

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Redox Control of the Cell Cycle in Health and Disease

Journal article

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Peer reviewed

Redox Control of the Cell Cycle in Health and Disease

Ehab H Sarsour, Maneesh G Kumar, Leena Chaudhuri, Amanda L Kalen and Prabhat C Goswami

Antioxidants & redox signaling, Vol.11(12), pp.2985-3011

12/2009

DOI: 10.1089/ars.2009.2513

PMCID: PMC2783918

PMID: 19505186

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Abstract

The cellular oxidation and reduction (redox) environment is influenced by the production and removal of reactive oxygen species (ROS). In recent years, several reports support the hypothesis that cellular ROS levels could function as ''second messengers'' regulating numerous cellular processes, including proliferation. Periodic oscillations in the cellular redox environment, a redox cycle, regulate cell-cycle progression from quiescence (G(0)) to proliferation (G(1), S, G(2), and M) and back to quiescence. A loss in the redox control of the cell cycle could lead to aberrant proliferation, a hallmark of various human pathologies. This review discusses the literature that supports the concept of a redox cycle controlling the mammalian cell cycle, with an emphasis on how this control relates to proliferative disorders including cancer, wound healing, fibrosis, cardiovascular diseases, diabetes, and neurodegenerative diseases. We hypothesize that reestablishing the redox control of the cell cycle by manipulating the cellular redox environment could improve many aspects of the proliferative disorders.

Details

Title: Subtitle: Redox Control of the Cell Cycle in Health and Disease
Creators: Ehab H Sarsour - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Maneesh G Kumar - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Leena Chaudhuri - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Amanda L Kalen - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Prabhat C Goswami - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Antioxidants & redox signaling, Vol.11(12), pp.2985-3011
DOI: 10.1089/ars.2009.2513
PMID: 19505186
PMCID: PMC2783918
NLM abbreviation: Antioxid Redox Signal
ISSN: 1523-0864
eISSN: 1557-7716
Language: English
Date published: 12/2009
Academic Unit: Radiation Oncology
Record Identifier: 9984047745602771

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