Journal article
Redox-Modulating Gene Therapies for Human Diseases
Antioxidants & redox signaling, Vol.3(3), pp.341-346
06/01/2001
DOI: 10.1089/15230860152408997
PMID: 11491648
Abstract
Baseline levels of reactive oxygen species (ROS) are generated as an integral component of cellular function. Under certain conditions,
e.g.
, the presence of an elevated concentration of transition
metal (Fe/Cu) ions, drug metabolism, or ischemia-reperfusion, ROS generation is exaggerated to an extent that overwhelms cellular antioxidant defenses and results in oxidative stress. Oxidative stress has
been characterized by the assessment of oxidative damage to cellular components,
e.g.
, protein, lipid, and nucleic acid. More recent studies have determined that at a concentration much below that
required for inflicting oxidative damage, ROS may serve as cellular second messengers through the regulation of numerous signal transduction pathways. For this reason, much of the current medical focus
in this area has been directed toward the understanding of redox-driven physiological and pathophysiological processes in the cell. The goal of such research is to formulate effective strategies for manipulating
the cellular redox environment in a manner that is beneficial for restoring normal cell functions in the setting of disease.
Details
- Title: Subtitle
- Redox-Modulating Gene Therapies for Human Diseases
- Creators
- John F. EngelhardtChandan K. SenLarry Oberley
- Resource Type
- Journal article
- Publication Details
- Antioxidants & redox signaling, Vol.3(3), pp.341-346
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/15230860152408997
- PMID
- 11491648
- ISSN
- 1523-0864
- eISSN
- 1557-7716
- Language
- English
- Date published
- 06/01/2001
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984284354302771
Metrics
31 Record Views