Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury

Kranti A. Mapuskar; Casey F. Pulliam; Diana Zepeda-Orozco; Benjamin R. Griffin; Muhammad Furqan; Douglas R. Spitz; Bryan G. Allen

doi:10.3390/antiox12091728

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Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury

Journal article

Open access

Peer reviewed

Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury

Kranti A. Mapuskar, Casey F. Pulliam, Diana Zepeda-Orozco, Benjamin R. Griffin, Muhammad Furqan, Douglas R. Spitz and Bryan G. Allen

Antioxidants, Vol.12(9), 1728

09/06/2023

DOI: 10.3390/antiox12091728

PMCID: PMC10525889

PMID: 37760031

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Abstract

Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulator of the antioxidant response, upregulating antioxidants and cytoprotective genes under oxidative stress. This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. We also explore Nrf2's signaling pathways, post-translational modifications, and its involvement in autophagy, as well as examine redox-based strategies for modulating Nrf2 in cisplatin-induced kidney injury while considering the limitations and potential off-target effects of Nrf2 modulation. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions. This knowledge could provide valuable insights into potential strategies for mitigating the nephrotoxicity associated with cisplatin, ultimately enhancing the safety and efficacy of cancer treatment.

Details

Title: Subtitle: Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
Creators: Kranti A. Mapuskar - University of Iowa Hospitals and Clinics
Casey F. Pulliam - University of Iowa
Diana Zepeda-Orozco - Nationwide Children's Hospital
Benjamin R. Griffin - University of Iowa Hospitals and Clinics
Muhammad Furqan - University of Iowa Hospitals and Clinics
Douglas R. Spitz - University of Iowa Hospitals and Clinics
Bryan G. Allen - University of Iowa
Resource Type: Journal article
Publication Details: Antioxidants, Vol.12(9), 1728
DOI: 10.3390/antiox12091728
PMID: 37760031
PMCID: PMC10525889
NLM abbreviation: Antioxidants (Basel)
ISSN: 2076-3921
eISSN: 2076-3921
Grant note: name: NIH, award: P01 CA217797; name: NIH, award: T32 CA078586
Language: English
Date published: 09/06/2023
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Nephrology; Internal Medicine
Record Identifier: 9984464515902771

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