Journal article
Redox Signaling in Cancer Biology
Antioxidants & redox signaling, Vol.8(7-8), pp.1249-1252
07/2006
DOI: 10.1089/ars.2006.8.1249
PMID: 16910772
Abstract
Over the last three decades, it is has become increasing clear that intracellular signaling pathways are activated via changes in intracellular metabolic oxidation/reduction (redox) reactions involving reactive oxygen species (ROS; i.e., superoxide and hydrogen peroxide). The initial proposals hypothesized that signaling through metabolic oxidation/reduction (redox) reactions involving ROS could contribute to carcinogenesis and progression to malignancy. Strong evidence for this hypothesis was obtained from studies showing that environmental insults (i.e., ionizing radiation) as well as xenobiotics (i.e., polycyclic aromatic hydrocarbons and phorbol esters) capable of inducing steady-state increases in free radical production and ROS could act as both initiators and promoters of carcinogenesis. This Forum is directed at understanding possible redox signaling mechanisms governing cellular radiation response, tumor growth, and response to therapy, as well as the role of nitric oxide in cancer biology.
Details
- Title: Subtitle
- Redox Signaling in Cancer Biology
- Creators
- David Gius - National Institutes of HealthDouglas R. Spitz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Antioxidants & redox signaling, Vol.8(7-8), pp.1249-1252
- DOI
- 10.1089/ars.2006.8.1249
- PMID
- 16910772
- ISSN
- 1523-0864
- eISSN
- 1557-7716
- Language
- English
- Date published
- 07/2006
- Academic Unit
- Pathology; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984312966802771
Metrics
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