Journal article
Redox-State-Driven Site Selectivity and Kinetic Gating in Polyoxovanadate Methylation
Inorganic chemistry, Vol.65(32), pp.18563-18571
08/06/2026
DOI: 10.1021/acs.inorgchem.6c01638
PMID: 42606270
Abstract
Polyoxovanadate clusters offer atomically defined platforms for studying how electronic structure influences reactivity at molecular metal-oxide surfaces. In this computational study, we investigated the coupling between reduction state and alkylation reactivity in the hexavanadate cluster [V6O13(TRIOLX)2]2– (TRIOL = tris(hydroxymethyl)methane; X = −CH3, −NO2) through a systematic analysis of successive methylation and reduction pathways using density functional theory and microkinetic modeling. The calculations show that changes in electron count redistribute the nucleophilicity of bridging μ2-oxo ligands, leading to redox-dependent regioselectivity during sequential methylation. Microkinetic simulations further indicate that several thermodynamically accessible intermediates do not accumulate because they are rapidly consumed in subsequent transformations, consistent with the need for stepwise synthetic strategies to isolate certain dimethylated species. In addition, substituent effects on the TRIOL ligands follow Hammett-type correlations, allowing rapid estimation of electronic trends without additional quantum chemical calculations. Overall, the results provide a detailed picture of how reduction state influences accessibility and selectivity during polyoxovanadate methylation.
Details
- Title: Subtitle
- Redox-State-Driven Site Selectivity and Kinetic Gating in Polyoxovanadate Methylation
- Creators
- Nghia Le - University of Iowa, ChemistryPere Miró - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Inorganic chemistry, Vol.65(32), pp.18563-18571
- DOI
- 10.1021/acs.inorgchem.6c01638
- PMID
- 42606270
- NLM abbreviation
- Inorg Chem
- ISSN
- 0020-1669
- eISSN
- 1520-510X
- Publisher
- American Chemical Society
- Grant note
- Division of Chemistry: 2145657
N.L. and P.M. thank the National Science Foundation for the support (NSF CAREER CHE-2145657 and CHE-2438306). All density functional theory calculations supporting this project were performed on high-performance computing systems at the University of Iowa.
- Language
- English
- Date published
- 08/06/2026
- Academic Unit
- Chemistry
- Record Identifier
- 9985218635802771
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