Journal article
Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation
Nature medicine, Vol.4(6), pp.698-704
06/1998
DOI: 10.1038/nm0698-698
PMID: 9623979
Abstract
Liver transplantation is the only therapeutic strategy for many inherited and acquired diseases. The formation of reactive oxygen species following ischemia/reperfusion is a cause of hepatocellular injury during transplantation. This report describes the therapeutic application of mitochondrial superoxide dismutase gene transfer to the liver for acute ischemia/reperfusion injury. Recombinant adenoviral expression of mitochondrial superoxide dismutase in mouse liver prior to lobar ischemia/reperfusion significantly reduced acute liver damage and associated redox activation of both NF-kappaB and AP1. These immediate early transcription factors represent common pathways by which cells respond to environmental stress. This work provides the foundation for redox-mediated gene therapies directed at ameliorating ischemia/reperfusion injury and associated acute rejection in orthotopic liver transplantation.
Details
- Title: Subtitle
- Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation
- Creators
- Ralf M ZwackaWeihong ZhouYulong ZhangChristine J DarbyLorita DudusJeff HalldorsonLarry OberleyJohn F Engelhardt
- Resource Type
- Journal article
- Publication Details
- Nature medicine, Vol.4(6), pp.698-704
- DOI
- 10.1038/nm0698-698
- PMID
- 9623979
- ISSN
- 1078-8956
- eISSN
- 1546-170X
- Language
- English
- Date published
- 06/1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984025329002771
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