Journal article
Redox regulation of S-nitrosocysteine-mediated vasodilation in vivo
European journal of pharmacology, Vol.408(2), pp.195-198
2000
DOI: 10.1016/S0014-2999(00)00779-2
PMID: 11080526
Abstract
This study examined the effects of the lipophobic electron acceptor, nitroblue tetrazolium (2×5 μmol/kg, i.v.) on the vasodilation produced by the putative endothelium-derived
S-nitrosothiol,
l-
S-nitrosocysteine (400 nmol/kg, i.v.), and the nitric oxide (NO) donor, (
Z)-1-|
N-methyl-
N-[6(
N-methylammoniohexyl)amino]|diazen-1-ium-1,2-diolate (MAHMA NONOate, 25 nmol/kg, i.v.), in anesthetized rats. The administration of nitroblue tetrazolium resulted in delayed but long-lasting increases in vascular resistances. The
l-
S-nitrosocysteine-induced vasodilator responses were markedly diminished whereas the MAHMA NONOate-induced responses were not affected by nitroblue tetrazolium. These results support the possibility that
l-
S-nitrosocysteine interacts with membrane thiols that are subject to nitroblue tetrazolium-induced oxidation (i.e., disulfide-bridge formation) and that nitroblue tetrazolium-induced vasoconstriction may involve a loss of potency of endothelium-derived
S-nitrosothiols.
Details
- Title: Subtitle
- Redox regulation of S-nitrosocysteine-mediated vasodilation in vivo
- Creators
- Azizul Hoque - Department of Cardiology, University of Louisville, Louisville, KY 40292, USAJames N Bates - Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USAStephen J Lewis - Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-7389, USA
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.408(2), pp.195-198
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0014-2999(00)00779-2
- PMID
- 11080526
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 2000
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006321902771
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