Journal article
Reduced Hedonic Behavior and Altered Cardiovascular Function Induced by Mild Sodium Depletion in Rats
Behavioral neuroscience, Vol.120(5), pp.1133-1143
10/2006
DOI: 10.1037/0735-7044.120.5.1133
PMID: 17014263
Abstract
Interactions among sodium homeostasis, fatigue, mood, and cardiovascular regulation have been described previously. The present study investigates the effects of sodium deficiency on an index of mood (hypohedonia; Experiment 1), cardiovascular function (Experiment 2), and plasma electrolytes (Experiment 3) in rats. Following 48 hr of sodium depletion with a diuretic (furosemide) and a sodium deficient diet, rats displayed hypohedonia evidenced by reduced responding for rewarding electrical brain stimulation into the hypothalamus. Also, sodium depletion produced increased heart rate and reduced heart rate variability. Plasma sodium levels were lower in sodium-depleted rats versus control rats, whereas potassium levels were unchanged. Thus, mild sodium depletion produces hypohedonia and cardiovascular alterations, which has implications for understanding behavioral and cardiovascular consequences of sodium deficiency.
Details
- Title: Subtitle
- Reduced Hedonic Behavior and Altered Cardiovascular Function Induced by Mild Sodium Depletion in Rats
- Creators
- Angela J Grippo - Department of Psychology and the Cardiovascular Center, University of IowaJulia A Moffitt - Department of Psychology and the Cardiovascular Center, University of IowaTerry G Beltz - Department of Psychology, University of IowaAlan Kim Johnson - Departments of Psychology, Integrative Psychology, Pharmacology, and the Cardiovascular Center, University of Iowa
- Contributors
- John F Disterhoft (Editor)
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.120(5), pp.1133-1143
- Publisher
- American Psychological Association
- DOI
- 10.1037/0735-7044.120.5.1133
- PMID
- 17014263
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health, award: MH-65839; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: HL-14388; HL-57472; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: DK-066086
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213270102771
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