Journal article
Reduced Presynaptic Dopamine Activity in Fibromyalgia Syndrome Demonstrated With Positron Emission Tomography: A Pilot Study
The journal of pain, Vol.8(1), pp.51-58
2007
DOI: 10.1016/j.jpain.2006.05.014
PMID: 17023218
Abstract
Although the pathophysiology underlying the pain of fibromyalgia syndrome (FMS) remains unknown, a variety of clinical and investigational findings suggests a dysregulation of dopaminergic neurotransmission. We therefore investigated presynaptic dopaminergic function in 6 female FMS patients in comparison to 8 age- and gender-matched controls as assessed by positron emission tomography with 6-[
18
F]fluoro-L-DOPA as a tracer. Semiquantitative analysis revealed reductions in 6-[
18
F]fluoro-L-DOPA uptake in several brain regions, indicating a disruption of presynaptic dopamine activity wherein dopamine plays a putative role in natural analgesia. Although the small sample size makes these findings preliminary, it appears that FMS might be characterized by a disruption of dopaminergic neurotransmission.
An association between FMS and reduced dopamine metabolism within the pain neuromatrix provides important insights into the pathophysiology of this mysterious disorder.
Details
- Title: Subtitle
- Reduced Presynaptic Dopamine Activity in Fibromyalgia Syndrome Demonstrated With Positron Emission Tomography: A Pilot Study
- Creators
- Patrick B Wood - Departments of Family Medicine and Anesthesiology, Louisiana State University Health Sciences Center–Shreveport, Shreveport, LouisianaJames C Patterson - Department of Psychiatry, Louisiana State University Health Sciences Center–Shreveport, Shreveport, LouisianaJohn J Sunderland - PET Imaging Center, Biomedical Research Foundation of Northwest Louisiana, Shreveport, LouisianaKerrie H Tainter - PET Imaging Center, Biomedical Research Foundation of Northwest Louisiana, Shreveport, LouisianaMichael F Glabus - PET Imaging Center, Biomedical Research Foundation of Northwest Louisiana, Shreveport, LouisianaDavid L Lilien - PET Imaging Center, Biomedical Research Foundation of Northwest Louisiana, Shreveport, Louisiana
- Resource Type
- Journal article
- Publication Details
- The journal of pain, Vol.8(1), pp.51-58
- DOI
- 10.1016/j.jpain.2006.05.014
- PMID
- 17023218
- NLM abbreviation
- J Pain
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2007
- Academic Unit
- Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984047871202771
Metrics
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