Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma

Michelle R Tamplin; Jui-Kai Wang; Anthony H Vitale; Ryuya Hashimoto; Mona K Garvin; Elaine M Binkley; Daniel E Hyer; John M Buatti; H Culver Boldt; Randy H Kardon; Isabella M Grumbach

doi:10.1186/s12886-022-02505-9

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Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma

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Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma

Michelle R Tamplin, Jui-Kai Wang, Anthony H Vitale, Ryuya Hashimoto, Mona K Garvin, Elaine M Binkley, Daniel E Hyer, John M Buatti, H Culver Boldt, Randy H Kardon, …

BMC ophthalmology, Vol.22(1), pp.285-285

06/28/2022

DOI: 10.1186/s12886-022-02505-9

PMCID: PMC9238054

PMID: 35765019

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Abstract

BACKGROUNDTo determine whether reductions in retinal and choroidal blood flow measured by laser speckle flowgraphy are detected after 125I-plaque brachytherapy for uveal melanoma. METHODSIn a cross-sectional study, retinal and choroidal blood flow were measured using laser speckle flowgraphy in 25 patients after treatment with 125I-plaque brachytherapy for uveal melanoma. Flow was analyzed in the peripapillary region by mean blur rate as well as in the entire image area with a novel superpixel-based method. Relationships between measures were determined by Spearman correlation. RESULTSSignificant decreases in laser speckle blood flow were observed in both the retinal and choroidal vascular beds of irradiated, but not fellow, eyes. Overall, 24 of 25 patients had decreased blood flow compared to their fellow eye, including 5 of the 6 patients imaged within the first 6 months following brachytherapy. A significant negative correlation between blood flow and time from therapy was present. CONCLUSIONSDecreases in retinal and choroidal blood flow by laser speckle flowgraphy were detected within the first 6 months following brachytherapy. Reduced retinal and choroidal blood flow may be an early indicator of microangiographic response to radiation therapy.

Details

Title: Subtitle: Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma
Creators: Michelle R Tamplin
Jui-Kai Wang
Anthony H Vitale
Ryuya Hashimoto
Mona K Garvin
Elaine M Binkley
Daniel E Hyer
John M Buatti
H Culver Boldt
Randy H Kardon
Isabella M Grumbach
Resource Type: Journal article
Publication Details: BMC ophthalmology, Vol.22(1), pp.285-285
DOI: 10.1186/s12886-022-02505-9
PMID: 35765019
PMCID: PMC9238054
NLM abbreviation: BMC Ophthalmol
eISSN: 1471-2415
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: T32 CA078586; DOI: 10.13039/100000968, name: American Heart Association, award: 18IPA34170003, 20PRE35110054; DOI: 10.13039/100000053, name: National Eye Institute, award: R01 EY031544, R01 EY031544; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: I50RX003002
Language: English
Date published: 06/28/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Iowa Neuroscience Institute; Cardiovascular Medicine; Radiation Oncology; Neurosurgery; Otolaryngology; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9984269759402771

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