Journal article
Reduced expression of dystroglycan in breast and prostate cancer
Human pathology, Vol.32(8), pp.791-795
2001
DOI: 10.1053/hupa.2001.26468
PMID: 11521221
Abstract
Cellular interactions with the extracellular matrix are an important factor in the development and progression of many types of cancer. Dystroglycan is a cell surface receptor for several extracellular matrix proteins and plays a central role in the formation of basement membranes in tissues. Because abnormalities in the structure and function of basement membranes are hallmarks of metastatic disease, we examined the status of dystroglycan expression in prostate and breast tumors. In 15 cases of surgically resected prostate cancer, we noted reduced expression of dystroglycan as judged by intensity of immunohistochemical staining. This reduction was most pronounced in high-grade disease. We found similar results in 6 cases of mammary ductal adenocarcinoma, suggesting that reduced expression of dystroglycan may be a conserved feature of epithelial neoplasia. These data suggest that reduced expression of dystroglycan in prostate and breast cancers may lead to abnormal cell-extracellular matrix interactions and thus contribute to progression to metastatic disease.
Details
- Title: Subtitle
- Reduced expression of dystroglycan in breast and prostate cancer
- Creators
- Michael D HENRY - Howard Hughes Medical Institute, Department of Physiology and Biophysics and the Department of Neurology, Department of Pathology, and Veterans Affairs Medical Center, University of Iowa College of Medicine, Iowa City, IA, United StatesMichael B COHEN - Howard Hughes Medical Institute, Department of Physiology and Biophysics and the Department of Neurology, Department of Pathology, and Veterans Affairs Medical Center, University of Iowa College of Medicine, Iowa City, IA, United StatesKevin P CAMPBELL - Howard Hughes Medical Institute, Department of Physiology and Biophysics and the Department of Neurology, Department of Pathology, and Veterans Affairs Medical Center, University of Iowa College of Medicine, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Human pathology, Vol.32(8), pp.791-795
- Publisher
- Elsevier; New York, NY
- DOI
- 10.1053/hupa.2001.26468
- PMID
- 11521221
- ISSN
- 0046-8177
- eISSN
- 1532-8392
- Language
- English
- Date published
- 2001
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Urology
- Record Identifier
- 9984020709302771
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