Journal article
Reduced haloperidol plasma concentration and clinical response in acute exacerbations of schizophrenia
Psychopharmacology, Vol.102(4), pp.514-520
12/1990
DOI: 10.1007/BF02247134
PMID: 2096408
Abstract
Twenty-nine hospitalized patients suffering acute exacerbations of schizophrenia were treated for 2 weeks with fixed daily oral doses of haloperidol prospectively calculated to achieve a haloperidol plasma concentration of either 8-18 ng/ml or 25-35 ng/ml. Reduced haloperidol as well as haloperidol concentrations were assayed to determine if the former enhanced the predictability of response. Wee 2 haloperidol plasma concentrations were negatively correlated to clinical response as measured by the percentage change in the BPRS score from baseline (r = -0.43, P less than 0.05). In contrast, week 2 plasma concentrations of reduced haloperidol, total haloperidol (haloperidol + reduced haloperidol), and reduced haloperidol/haloperidol ratio did not correlate with the change in the BPRS score. Chi-square analysis concluded that patients with ratios greater than one were no less likely to be treatment responders (less than 25% improvement in BPRS from baseline and week 2 BPRS less than 55) than those with ratios less than one. Although these data lend additional support to reports of a curvilinear relationship between haloperidol plasma concentration and clinical response, they also suggest that reduced haloperidol plasma concentrations are of no value in predicting treatment response.
Details
- Title: Subtitle
- Reduced haloperidol plasma concentration and clinical response in acute exacerbations of schizophrenia
- Creators
- Michael W KellyPaul J PerryWilliam H CoryellDel D MillerStephan V Arndt
- Resource Type
- Journal article
- Publication Details
- Psychopharmacology, Vol.102(4), pp.514-520
- DOI
- 10.1007/BF02247134
- PMID
- 2096408
- NLM abbreviation
- Psychopharmacology (Berl)
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- Language
- English
- Date published
- 12/1990
- Academic Unit
- Pharmacy; Psychiatry; Biostatistics; Nursing; Pharmacy Practice and Science; Injury Prevention Research Center
- Record Identifier
- 9984004183702771
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