Journal article
Reduced minicolumns in the frontal cortex of patients with autism
Neuropathology and applied neurobiology, Vol.32(5), pp.483-491
10/2006
DOI: 10.1111/j.1365-2990.2006.00745.x
PMID: 16972882
Abstract
Cell minicolumns were shown to be narrower in frontal regions in brains of autistic patients compared with controls. This was not found in primary visual cortex. Within the frontal cortex, dorsal and orbital regions displayed the greatest differences while the mesial region showed the least change. We also found that minicolumns in the brain of a 3-year-old autistic child were indistinguishable from those of the autistic adult in two of three frontal regions, in contrast to the control brains. This may have been due to the small size of the columns in the adult autistic brain rather than to an accelerated development. The presence of narrower minicolumns supports the theory that there is an abnormal increase in the number of ontogenetic column units produced in some regions of the autistic brain during corticoneurogenesis.
Details
- Title: Subtitle
- Reduced minicolumns in the frontal cortex of patients with autism
- Creators
- D P Buxhoeveden - Department of Anthropology, University of South Carolina, Columbia, SC, USA. buxhoevede@gwm.sc.eduK SemendeferiJ BuckwalterN SchenkerR SwitzerE Courchesne
- Resource Type
- Journal article
- Publication Details
- Neuropathology and applied neurobiology, Vol.32(5), pp.483-491
- Publisher
- England
- DOI
- 10.1111/j.1365-2990.2006.00745.x
- PMID
- 16972882
- ISSN
- 0305-1846
- eISSN
- 1365-2990
- Grant note
- DA13137 / NIDA NIH HHS
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984001212302771
Metrics
19 Record Views