Reduced morbidity with early surgical ligation of patent ductus arteriosus in extremely low birth weight infants: a retrospective single-centre study

Katherine A. Loeffler; Shashank P. Behere; Patricia K. Williams; Yuki Nakamura; Harold M. Burkhart; Matthew D. Campbell

doi:10.1017/S1047951123004432

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Reduced morbidity with early surgical ligation of patent ductus arteriosus in extremely low birth weight infants: a retrospective single-centre study

Journal article

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Reduced morbidity with early surgical ligation of patent ductus arteriosus in extremely low birth weight infants: a retrospective single-centre study

Katherine A. Loeffler, Shashank P. Behere, Patricia K. Williams, Yuki Nakamura, Harold M. Burkhart and Matthew D. Campbell

Cardiology in the young, Vol.34(6), pp.1279-1284

06/01/2024

DOI: 10.1017/S1047951123004432

PMID: 38196381

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Abstract

Introduction: Failure of the patent ductus arteriosus to close is common among extremely low birth weight neonates and has been associated with increased morbidities. The objective of this study was to compare outcomes between early and late surgical ligation in extremely low birth weight patients.Methods: This was a single-centre retrospective cohort study of infants who required surgical closure of patent ductus arteriosus between January 2017 and August 2022.Results: A total of 43 neonates were identified with birth weight less than 1 kg that underwent surgical patent ductus arteriosus ligation. Compared to the late ligation group, the early ligation group experienced fewer total days of mechanical ventilation (43.9 days vs. 97.2 days, p < 0.05) and a shorter length of hospital stay (114.2 days vs. 169.0 days, p < 0.05).Conclusion: Early surgical ligation of haemodynamically significant patent ductus arteriosus in extremely low birth weight neonates may improve hospital morbidity, including improved ventilatory outcomes and a shorter length of stay.

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Pediatrics

Science & Technology

Details

Title: Subtitle: Reduced morbidity with early surgical ligation of patent ductus arteriosus in extremely low birth weight infants: a retrospective single-centre study
Creators: Katherine A. Loeffler - University of Oklahoma
Shashank P. Behere - University of Oklahoma
Patricia K. Williams - University of Oklahoma
Yuki Nakamura - University of Oklahoma
Harold M. Burkhart - University of Oklahoma
Matthew D. Campbell - University of Oklahoma
Resource Type: Journal article
Publication Details: Cardiology in the young, Vol.34(6), pp.1279-1284
DOI: 10.1017/S1047951123004432
PMID: 38196381
NLM abbreviation: Cardiol Young
ISSN: 1047-9511
eISSN: 1467-1107
Publisher: Cambridge Univ Press
Number of pages: 6
Language: English
Date published: 06/01/2024
Academic Unit: Cardiothoracic Surgery
Record Identifier: 9985164049902771

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