Journal article
Reduced risk of pancreatic cancer associated with asthma and nasal allergies
Gut, Vol.66(2), pp.314-322
02/2017
DOI: 10.1136/gutjnl-2015-310442
PMID: 26628509
Abstract
Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.
Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model.
Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk.
This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.
Details
- Title: Subtitle
- Reduced risk of pancreatic cancer associated with asthma and nasal allergies
- Creators
- Paulina Gomez-Rubio - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, SpainJan-Paul Zock - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainMarta Rava - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, SpainMirari Marquez - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, SpainLinda Sharp - National Cancer Registry Ireland, Cork, Ireland, and Institute of Health & Society, Newcastle University, UKManuel Hidalgo - Hospital Madrid-Norte-Sanchinarro, Madrid, SpainAlfredo Carrato - Department of Oncology, Hospital Ramón y Cajal, Madrid, SpainLucas Ilzarbe - Hospital del Mar-Parc de Salut Mar, Barcelona, SpainChristoph Michalski - Technical University of Munich, Munich, GermanyXavier Molero - Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, SpainAntoni Farré - Hospital de la Santa Creu i Sant Pau, Barcelona, SpainJosé Perea - Department of Surgery, 12 de Octubre University Hospital, Madrid, SpainWilliam Greenhalf - The Royal Liverpool University Hospital, Liverpool, UKMichael O'Rorke - Centre for Public Health, Queen's University Belfast, Belfast, UKAdonina Tardón - Instituto Universitario de Oncología del Principado de Asturias, Oviedo, SpainThomas Gress - Department of Gastroenterology, University Hospital Giessen and Marburg, Marburg, GermanyVictor Barberà - Laboratorio de Genética Molecular, Hospital General Universitario de Elche, Elche, SpainTatjana Crnogorac-Jurcevic - Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UKEnrique Domínguez-Muñoz - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, SpainLuís Muñoz-Bellvís - Cirugía General y del Aparato Digestivo, Hospital Universitario de Salamanca, Salamanca, SpainCristina Alvarez-Urturi - Hospital del Mar-Parc de Salut Mar, Barcelona, SpainJoaquim Balcells - Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, SpainLuis Barneo - Instituto Universitario de Oncología del Principado de Asturias, Oviedo, SpainEithne Costello - The Royal Liverpool University Hospital, Liverpool, UKCarmen Guillén-Ponce - Department of Oncology, Hospital Ramón y Cajal, Madrid, SpainJörg Kleeff - Technical University of Munich, Munich, GermanyBo Kong - Technical University of Munich, Munich, GermanyRita Lawlor - Department of Pathology and Diagnostics, University of Verona, Verona, ItalyMatthias Löhr - Gastrocentrum, Karolinska Institutet, Stockholm, SwedenJosefina Mora - Hospital de la Santa Creu i Sant Pau, Barcelona, SpainLim Murray - Centre for Public Health, Queen's University Belfast, Belfast, UKDamian O'Driscoll - National Cancer Registry Ireland, Cork, Ireland, and Institute of Health & Society, Newcastle University, UKPablo Peláez - Department of Surgery, 12 de Octubre University Hospital, Madrid, SpainIgnasi Poves - Hospital del Mar-Parc de Salut Mar, Barcelona, SpainAldo Scarpa - Department of Pathology and Diagnostics, University of Verona, Verona, ItalyFrancisco X Real - Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, SpainNúria Malats - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, SpainPanGenEU Study Investigators
- Resource Type
- Journal article
- Publication Details
- Gut, Vol.66(2), pp.314-322
- DOI
- 10.1136/gutjnl-2015-310442
- PMID
- 26628509
- NLM abbreviation
- Gut
- ISSN
- 0017-5749
- eISSN
- 1468-3288
- Publisher
- England
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9983995169802771
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