Journal article
Reduced susceptibility to confirmation bias in schizophrenia
Cognitive, affective, & behavioral neuroscience, Vol.14(2), pp.715-728
06/01/2014
DOI: 10.3758/s13415-014-0250-6
PMCID: PMC4074440
PMID: 24481852
Abstract
Patients with schizophrenia (SZ) show cognitive impairments on a wide range of tasks, with clear deficiencies in tasks reliant on prefrontal cortex function and less consistently observed impairments in tasks recruiting the striatum. This study leverages tasks hypothesized to differentially recruit these neural structures to assess relative deficiencies of each. Forty-eight patients and 38 controls completed two reinforcement learning tasks hypothesized to interrogate prefrontal and striatal functions and their interaction. In each task, participants learned reward discriminations by trial and error and were tested on novel stimulus combinations to assess learned values. In the task putatively assessing fronto-striatal interaction, participants were (inaccurately) instructed that one of the stimuli was valuable. Consistent with prior reports and a model of confirmation bias, this manipulation resulted in overvaluation of the instructed stimulus after its true value had been experienced. Patients showed less susceptibility to this confirmation bias effect than did controls. In the choice bias task hypothesized to more purely assess striatal function, biases in endogenously and exogenously chosen actions were assessed. No group differences were observed. In the subset of participants who showed learning in both tasks, larger group differences were observed in the confirmation bias task than in the choice bias task. In the confirmation bias task, patients also showed impairment in the task conditions with no prior instruction. This deficit was most readily observed on the most deterministic discriminations. Taken together, these results suggest impairments in fronto-striatal interaction in SZ, rather than in striatal function per se.
Details
- Title: Subtitle
- Reduced susceptibility to confirmation bias in schizophrenia
- Creators
- Bradley B. Doll - New York UniversityJames A. Waltz - University of Maryland, BaltimoreJeffrey Cockburn - Brown UniversityJaime K. Brown - University of Maryland, BaltimoreMichael J. Frank - Brown UniversityJames M. Gold - University of Maryland, Baltimore
- Resource Type
- Journal article
- Publication Details
- Cognitive, affective, & behavioral neuroscience, Vol.14(2), pp.715-728
- DOI
- 10.3758/s13415-014-0250-6
- PMID
- 24481852
- PMCID
- PMC4074440
- NLM abbreviation
- Cogn Affect Behav Neurosci
- ISSN
- 1530-7026
- eISSN
- 1531-135X
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- R01MH080066 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01 MH080066 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984696652702771
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