Journal article
Reduced thirst in old, thermally dehydrated rats
Physiology & behavior, Vol.81(4), pp.569-576
2004
DOI: 10.1016/j.physbeh.2004.02.030
PMID: 15178149
Abstract
Water intake and blood parameters of young (7-month) and old (23-month) male Brown Norway rats were assessed following a period of thermal dehydration. Rats of both ages were randomly assigned to one of three groups: (1) Unheated-blood sample, (2) Heated-blood sample, and (3) Heated-water intake. The colonic temperature of heated rats was raised at the rate of 0.05 °C/min for 1 h using an infrared heat lamp. Water intake was then measured over the following 2 h. The heating protocol resulted in a similar level of dehydration in both young and old rats; however, plasma osmolality and sodium concentration increased to a significant extent only in the young rats. Old rats drank significantly less water at all time points during the 2 h following the heat stress. While neither group replaced the water lost as a result of the thermal dehydration, the young rats did rehydrate to a greater extent. These results suggest that the diminished level of rehydration in aged rats, following a thermal dehydration, is due to an attenuated rise in plasma osmolality.
Details
- Title: Subtitle
- Reduced thirst in old, thermally dehydrated rats
- Creators
- Douglas G Whyte - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USARobert L Thunhorst - Department of Psychology, University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USAAlan Kim Johnson - Department of Psychology, University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- Physiology & behavior, Vol.81(4), pp.569-576
- DOI
- 10.1016/j.physbeh.2004.02.030
- PMID
- 15178149
- NLM abbreviation
- Physiol Behav
- ISSN
- 0031-9384
- eISSN
- 1873-507X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2004
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213270502771
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