Journal article
Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI
Cardiovascular drugs and therapy, Vol.25(3), pp.243-250
06/01/2011
DOI: 10.1007/s10557-011-6301-0
PMID: 21584633
Abstract
PURPOSEThe objective of our study was to identify changes in the coagulation and serum concentration of soluble P-selectin (sP-sel) after i.v. bolus of 0.75 mg/kg enoxaparin in a group of 33 patients during PCI.METHODS AND RESULTSAs compared to baseline, i.v. enoxaparin increased anti -Xa activity and FIIa inhibition together with APTT and thrombin time tests within 20 min, that persisted for 60 min. At 6 h, the results of all tests had returned to baseline. In contrast, the level of prothrombin fragments (F1 + 2) decreased persistingly for a period of 6 h (baseline 1.19 ± 0.42 nmol/l, after 20 min 1.03 ± 0.46 nmol/l, after 60 min 1.06 ± 0.43 nmol/l, after 6 h 0.95 ± 0.40 nmol/l, p < 0.001 vs. baseline for all values). In addition, i.v. enoxaparin decreased serum sP-sel level (baseline 111.80 ± 37.05 ng/ml, after 20 min 87.80 ± 33.17 ng/ml, after 60 min 86.45 ± 29.15 ng/ml, after 6 h 92.24 ± 31.34 ng/ml, p < 0.001 vs. baseline value for all). sP-sel level mildly correlated with both F Xa inhibition (r = -0.275, p < 0.05) and F1 + 2 level (r = 0.274, p < 0.05).CONCLUSIONIntravenous enoxaparin induced target F Xa inhibition (>0.6 IU/ml) for 60 min in 82% of study patients. During the 6 h of monitoring, a decrease of thrombin generation (F1 + 2) and sP-selectin levels were observed.
Details
- Title: Subtitle
- Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI
- Creators
- J Kvasnička - Charles UniversityJ Horák - Charles UniversityZ Zenáhlíková - Charles UniversityTomáš Kvasnička - Charles UniversityS Simek - Charles UniversityT Kovárník - Charles UniversityI Malíková - Charles UniversityA Linhart - Charles UniversityM Aschermann - Charles University
- Resource Type
- Journal article
- Publication Details
- Cardiovascular drugs and therapy, Vol.25(3), pp.243-250
- DOI
- 10.1007/s10557-011-6301-0
- PMID
- 21584633
- ISSN
- 0920-3206
- eISSN
- 1573-7241
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984627326402771
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