Journal article
Reducing Capillary Leak Syndrome Mortality in Extremely Premature Infants: A Pilot Investigation
Clinical pediatrics, Vol.64(3), pp.425-433
03/2025
DOI: 10.1177/00099228241272037
PMID: 39123307
Abstract
Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition.Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition.
Details
- Title: Subtitle
- Reducing Capillary Leak Syndrome Mortality in Extremely Premature Infants: A Pilot Investigation
- Creators
- Timothy J Boly - University of IowaMichell M Lozano-Chinga - University of IowaMelanie E Reyes-Hernandez - University of Iowa, Stead Family Department of PediatricsTimothy G Elgin - University of Wisconsin–MadisonZuhair Ballas - University of IowaJennifer R Bermick - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical pediatrics, Vol.64(3), pp.425-433
- Publisher
- SAGE PUBLICATIONS INC; THOUSAND OAKS
- DOI
- 10.1177/00099228241272037
- PMID
- 39123307
- ISSN
- 1938-2707
- eISSN
- 1938-2707
- Language
- English
- Electronic publication date
- 08/09/2024
- Date published
- 03/2025
- Academic Unit
- Stead Family Department of Pediatrics; Immunology; Neonatology; Internal Medicine
- Record Identifier
- 9984696855202771
Metrics
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