Journal article
Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration
CrystEngComm, Vol.19(27), pp.3723-3726
2017
DOI: 10.1039/C7CE00826K
Abstract
We report the preparation and dehydration of a cocrystal of caffeine and 2,4-dihydroxybenzoic acid. The dehydration of cocrystals of macro-dimensions results in destruction of crystal morphology; however, crystal morphology is retained when the cocrystal is reduced to nanometer-dimensions, despite a lack of pores to accommodate loss of water.
Details
- Title: Subtitle
- Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration
- Creators
- Katherine E Peterson - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USA, Research and DevelopmentRodger F Henry - Research and Development, Abbvie, Inc., North Chicago, USAGeoff G. Z Zhang - Research and Development, Abbvie, Inc., North Chicago, USALeonard R MacGillivray - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USA
- Resource Type
- Journal article
- Publication Details
- CrystEngComm, Vol.19(27), pp.3723-3726
- DOI
- 10.1039/C7CE00826K
- ISSN
- 1466-8033
- eISSN
- 1466-8033
- Grant note
- DOI: 10.13039/100006483, name: AbbVie
- Language
- English
- Date published
- 2017
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984216726002771
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