Journal article
Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist
Pain (Amsterdam), Vol.59(1), pp.95-100
1994
DOI: 10.1016/0304-3959(94)90052-3
PMID: 7854809
Abstract
The experimental arthritis of the knee joint used in the present study leads to joint swelling, increased joint temperature, limping, guarding, and a decrease in paw withdrawal latency (PWL) to radiant heat (hyperalgesia) within hours in rats. Unexpectedly, administration of the non-NMDA receptor antagonist, CNQX, in the spinal cord 4 h after initiation of the arthritis significantly reduced the degree of joint inflammation and returned PWL times to baseline. Therefore, the present results indicate that established joint swelling and hyperalgesia can be reduced significantly by CNQX.
Details
- Title: Subtitle
- Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist
- Creators
- K. A SLUKA - Univ. Texas medical branch, marine biochemical inst., dep. anatomy neurosci., Galveston TX 77555-0843, United StatesH. H JORDAN - Univ. Texas medical branch, marine biochemical inst., dep. anatomy neurosci., Galveston TX 77555-0843, United StatesK. N WESTLUND - Univ. Texas medical branch, marine biochemical inst., dep. anatomy neurosci., Galveston TX 77555-0843, United States
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.59(1), pp.95-100
- Publisher
- Elsevier; Amsterdam
- DOI
- 10.1016/0304-3959(94)90052-3
- PMID
- 7854809
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Language
- English
- Date published
- 1994
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040449802771
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