Journal article
Reduction of pain-related behaviors with either cold or heat treatment in an animal model of acute arthritis
Archives of physical medicine and rehabilitation, Vol.80(3), pp.313-317
1999
DOI: 10.1016/S0003-9993(99)90143-0
PMID: 10084440
Abstract
Objective: To assess the effects of heat and cold on quantifiable pain behaviors in an animal model of arthritis that minimizes the motivational-affective component of pain.
Design: The effects of superficial heat (40°C) and cold (4°C) on pain behaviors in rats with knee joint inflammation were tested before and after induction of inflammation and after treatment with heat or cold.
Subjects: Joint inflammation was induced in male Sprague-Dawley rats by intra-articular injection of the knee joint with 3% kaolin and 3% carrageenan.
Main Outcome Measures: Withdrawal latency to heat applied to the paw (PWL) assessed secondary hyperalgesia; spontaneous pain behaviors assessed degree of weight bearing/guarding; and joint circumference assessed joint swelling.
Results: Cold treatment of the inflamed knee joint significantly reversed the PWL immediately after treatment (
p = .003) without affecting spontaneous pain behaviors or joint circumference. In contrast, heat treatment produced a small but significant decrease in spontaneous pain behaviors (
p = .03) without affecting PWL or joint circumference.
Conclusion: Acute arthritic pain can be treated with either superficial heat for reducing guarding or with cold for reducing pain or hyperalgesia outside the injury site.
Details
- Title: Subtitle
- Reduction of pain-related behaviors with either cold or heat treatment in an animal model of acute arthritis
- Creators
- Kathleen A Sluka - Physical Therapy Graduate Program, College of Medicine, The University of Iowa, Iowa City, IA, USAMichelle R Christy - Physical Therapy Graduate Program, College of Medicine, The University of Iowa, Iowa City, IA, USAWendy L Peterson - Physical Therapy Graduate Program, College of Medicine, The University of Iowa, Iowa City, IA, USAStaci L Rudd - Physical Therapy Graduate Program, College of Medicine, The University of Iowa, Iowa City, IA, USAStacie M Troy - Physical Therapy Graduate Program, College of Medicine, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Archives of physical medicine and rehabilitation, Vol.80(3), pp.313-317
- DOI
- 10.1016/S0003-9993(99)90143-0
- PMID
- 10084440
- NLM abbreviation
- Arch Phys Med Rehabil
- ISSN
- 0003-9993
- eISSN
- 1532-821X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1999
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040247102771
Metrics
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