Journal article
Reductive Cross-Coupling of Nonaromatic, Heterocyclic Bromides with Aryl and Heteroaryl Bromides
Journal of organic chemistry, Vol.79(12), pp.5771-5780
06/20/2014
DOI: 10.1021/jo500905m
PMID: 24892751
Abstract
Reductive cross-coupling allows the direct C-C bond formation between two organic halides without the need for preformation of an organometallic reagent. A method has been developed for the reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl or heteroaryl bromides. The developed conditions use an air-stable Ni(II) source in the presence of a diamine ligand and a metal reductant to allow late-stage incorporation of saturated heterocyclic rings onto aryl halides in a functional-group tolerant manner.
Details
- Title: Subtitle
- Reductive Cross-Coupling of Nonaromatic, Heterocyclic Bromides with Aryl and Heteroaryl Bromides
- Creators
- Gary A Molander - Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United StatesKaitlin M Traister - Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United StatesBrian T O’Neill - Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States
- Resource Type
- Journal article
- Publication Details
- Journal of organic chemistry, Vol.79(12), pp.5771-5780
- DOI
- 10.1021/jo500905m
- PMID
- 24892751
- NLM abbreviation
- J Org Chem
- ISSN
- 0022-3263
- eISSN
- 1520-6904
- Language
- English
- Date published
- 06/20/2014
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094376302771
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