Journal article
Reference values for high attenuation areas on chest CT in a healthy, never‐smoker, multi‐ethnic sample: The MESA study
Respirology (Carlton, Vic.), Vol.25(8), pp.855-862
08/2020
DOI: 10.1111/resp.13783
PMCID: PMC8176866
PMID: 32064731
Abstract
Background and objective: Normative values for HAA—a quantitative, CT-based measure of subclinical ILD—in healthy adults are needed to improve interpretability in clinical and research settings. Methods: HAA was measured on full-lung CT in 3110 participants in the MESA study. Clinical prediction models were developed using a healthy never-smoker subset with normal spirometry (n = 696). RMSE on cross-validation was used as the primary criterion for model selection. Parametric and non-parametric methods were considered. z-Scores were calculated for the entire study sample. Associations between z-scores and several ILD features were estimated. Results: In the healthy never-smoker subset, the mean age was 69 years with a range of 54–93 years. The median HAA was 4.3% with a range of 2.7–17.8%. Linear regression had better predictive performance than other methods. The final model included race, height, weight, age and sex. The standard error of the estimate was 1.62 with a cross-validated RMSE of 1.64 and an adjusted R2 of 0.139. z-Scores were associated with several ILD outcomes in adjusted models, including ILA (OR: 1.40 per z-unit; 95% CI: 1.30, 1.52), exertional dyspnoea (OR: 1.08 per z-unit; 95% CI: 1.02, 1.15) and FVC (expected increase per z-unit: −2.49; 95% CI: −2.95, − 2.03). Conclusion: We present a reference equation and z-scores to define expected values of HAA on full-lung CT to aid HAA interpretation in middle-aged and older adults.
Details
- Title: Subtitle
- Reference values for high attenuation areas on chest CT in a healthy, never‐smoker, multi‐ethnic sample: The MESA study
- Creators
- Imaani Easthausen - Columbia UniversityAnna Podolanczuk - Columbia UniversityEric Hoffman - Roy J. and Lucille A. Carver College of MedicineSteven Kawut - University of PennsylvaniaElizabeth Oelsner - Columbia UniversityJohn S. Kim - University of VirginiaGanesh Raghu - University of WashingtonKaren Hinckley Stukovsky - University of WashingtonSusan Redline - Harvard UniversityRobyn L. McClelland - University of WashingtonR Graham Barr - Columbia UniversityDavid J. Lederer - Columbia University
- Resource Type
- Journal article
- Publication Details
- Respirology (Carlton, Vic.), Vol.25(8), pp.855-862
- DOI
- 10.1111/resp.13783
- PMID
- 32064731
- PMCID
- PMC8176866
- NLM abbreviation
- Respirology
- ISSN
- 1323-7799
- eISSN
- 1440-1843
- Grant note
- DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1‐TR‐000040, UL1‐TR‐001079, UL1‐TR‐001420; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: N01‐HC‐95159, N01‐HC‐95160, N01‐HC‐95161, N01‐HC‐95162, N01‐HC‐95163, N01‐HC‐95164, N01‐HC‐95165, N01‐HC‐95166, N01‐HC‐95167, N01‐HC‐95168, N01‐HC‐95169, R01‐HL103676, R01‐HL‐103676‐S1, K24‐HL‐131937, R01 HL077612, K24 HL103844, R01 HL093081; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: HSN268201500003I
- Language
- English
- Date published
- 08/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318694402771
Metrics
35 Record Views