Journal article
Refined localization and two additional linked families for the DFNA10 locus for nonsyndromic hearing impairment
Human genetics, Vol.107(1), pp.7-11
07/2000
DOI: 10.1007/s004390000319
PMID: 10982027
Abstract
DFNA10 originally was mapped to the long arm of chromosome 6 in a large American family segregating for autosomal dominant progressive nonsyndromic hearing impairment. By extending this American family, we have reduced the original DFNA10 candidate region from 13 cM to 3.7 cM. We also report a Belgian family with autosomal dominant nonsyndromic hearing impairment linked to DFNA10 and a Norwegian family with the same condition in which linkage is suggestive, although maximum lod scores are only 2.5. The hearing phenotype in all three DFNA10 families is similar, with losses beginning in the middle frequencies and involving the low and high frequencies later in life.
Details
- Title: Subtitle
- Refined localization and two additional linked families for the DFNA10 locus for nonsyndromic hearing impairment
- Creators
- Kristien Verhoeven - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, BelgiumToril Fagerheim - Department of Medical Genetics, University Hospital, 9038 Tromsö, NorwaySai Prasad - Department of Otolaryngology, University of Iowa, Iowa City, Iowa 52242, USASigrid Wayne - Department of Otolaryngology, University of Iowa, Iowa City, Iowa 52242, USAFrank De Clau - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, BelgiumWendy Balemans - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, BelgiumMargriet Verstreken - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, BelgiumIsabelle Schatteman - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, BelgiumBjorn Solem - Department of Oto-Rhino-laryngology, University Hospital of Tromsö, NorwayPaul Van de Heyning - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, BelgiumLisbeth Tranebjärg - Department of Medical Genetics, University Hospital, 9038 Tromsö, NorwayRichard J. H Smith - Department of Otolaryngology, University of Iowa, Iowa City, Iowa 52242, USAGuy Van Camp - Department of Medical Genetics and ENT Department, University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, Belgium
- Resource Type
- Journal article
- Publication Details
- Human genetics, Vol.107(1), pp.7-11
- DOI
- 10.1007/s004390000319
- PMID
- 10982027
- NLM abbreviation
- Hum Genet
- ISSN
- 0340-6717
- eISSN
- 1432-1203
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Language
- English
- Date published
- 07/2000
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006339402771
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