Journal article
Reflex Inhibition of Renal Sympathetic Nerve Activity during Myocardial Ischemia Mediated by Left Ventricular Receptors with Vagal Afferents in Dogs
The Journal of clinical investigation, Vol.63(3), pp.395-402
03/1979
DOI: 10.1172/JCI109315
PMID: 429560
Abstract
The major goal of this investigation was to determine if activation of cardiac receptors during coronary artery occlusion could inhibit efferent renal sympathetic nerve activity. In nine chloralose anesthetized dogs with only carotid (\nn\n= 3) or with sinoaortic (\nn\n= 6) baroreceptors operative, anterior descending coronary artery (LAD) occlusion resulted in a small decrease in mean arterial pressure (−9.8±5.1 mm Hg, NS) and in a significant (\nP\n< 0.05) increase in renal nerve activity (24.0±4.1%). In these dogs, circumflex coronary artery (Cx) occlusion resulted in greater hypotension (−18.4±4.0 mm Hg), and yet no change (1.1±9%) in renal nerve activity was noted. Changes in left atrial pressure during LAD and Cx occlusion were not different. In seven dogs with carotid sinus denervation, coronary occlusions resulted in decreases both in arterial pressure and in renal nerve activity which were consistently greater during Cx occlusion. The responses to coronary occlusion in six dogs after sinoaortic deafferentation were similar to those observed with only carotid sinuses denervated. In all experiments, vagotomy abolished the difference in the blood pressure responses and the decreases in renal sympathetic nerve activity during Cx occlusion. Vagotomy also abolished the decrease in nerve activity during LAD occlusion in dogs with carotid or sinoaortic denervation. These data show that Cx occlusion and, to a lesser degree, LAD occlusion resulted in reflex withdrawal of renal sympathetic nerve activity mediated by left ventricular receptors with vagal afferents. The reflex withdrawal of renal nerve activity during Cx occlusion occurred in spite of hypotension and the presence of functioning sinoaortic baroreceptors.
Details
- Title: Subtitle
- Reflex Inhibition of Renal Sympathetic Nerve Activity during Myocardial Ischemia Mediated by Left Ventricular Receptors with Vagal Afferents in Dogs
- Creators
- Marc D Thames - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242Francois M Abboud - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.63(3), pp.395-402
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI109315
- PMID
- 429560
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 03/1979
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025345002771
Metrics
33 Record Views