Reflex modulation of carotid sinus baroreceptor activity in the dog

Robert B Felder; Cheryl M Heesch; Marc D Thames

doi:10.1152/ajpheart.1983.244.3.H437

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Reflex modulation of carotid sinus baroreceptor activity in the dog

Journal article

Peer reviewed

Reflex modulation of carotid sinus baroreceptor activity in the dog

Robert B Felder, Cheryl M Heesch and Marc D Thames

The American journal of physiology, Vol.244(3), pp.H437-443

03/1983

DOI: 10.1152/ajpheart.1983.244.3.H437

PMID: 6829786

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Abstract

Carotid sinus baroreceptor (CBR) sensitivity may be increased by electrical stimulation of sympathetic nerves passing to the carotid sinus region. It remains unknown if reflexly induced changes in efferent sympathetic discharge affect CBR function. In 17 anesthetized dogs, we reflexly induced alterations in sympathetic discharge and recorded CBR activity originating from a vascularly isolated carotid sinus. The stimulus to the baroreceptors was pulsatile with constant mean and pulse pressure. Occlusion of the contralateral common carotid artery (n = 6) resulted in a reflex increase in arterial pressure (116 +/- 10 to 153 +/- 14 mmHg) and an increase (121 +/- 2% of control) in baroreceptor activity (P less than 0.05). Inferior vena caval occlusion (n = 6), which induced a reduction in arterial pressure (145 +/- 19 to 75 +/- 21 mmHg), also provoked an increase (141 +/- 10% of control) in baroreceptor discharge (P less than 0.05). Raising pressure (to 200 mmHg) in the contralateral carotid sinus (n = 7) resulted in a reflex decrease in arterial pressure (169 +/- 16 to 129 +/- 13 mmHg) and a reduction (82 +/- 3% of control) in baroreceptor activity (P less than 0.05). The changes in baroreceptor discharge were abolished by ipsilateral cervical sympathectomy or ganglionic blockade (n = 4). Our findings demonstrate that reflexly induced alterations in the activity of sympathetic fibers innervating the carotid sinuses can modulate baroreceptor discharge.

Reflex

Animals

Dogs

Pressoreceptors - physiology

Carotid Sinus - physiology

Blood Pressure - drug effects

Protoveratrines - pharmacology

Bradykinin - pharmacology

Carotid Sinus - drug effects

Nicotine - pharmacology

Pressoreceptors - drug effects

Veratrine - pharmacology

Details

Title: Subtitle: Reflex modulation of carotid sinus baroreceptor activity in the dog
Creators: Robert B Felder
Cheryl M Heesch
Marc D Thames
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.244(3), pp.H437-443
DOI: 10.1152/ajpheart.1983.244.3.H437
PMID: 6829786
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: United States
Grant note: HL-00402 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-21158 / NHLBI NIH HHS
Language: English
Date published: 03/1983
Academic Unit: Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984065495702771

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