Journal article
Refractory NMDA-receptor encephalitis in a teenager: A novel use of Bortezomib
Journal of neuroimmunology, Vol.355, p.577565
06/15/2021
DOI: 10.1016/j.jneuroim.2021.577565
PMID: 33813318
Abstract
We report the case of a 14-year-old girl who was diagnosed with N-methyl-D-aspartate (NMDA)-receptor encephalitis, with severe features and autonomic instability, requiring intensive care unit admission. She had poor clinical response to the first-line therapies, she was then started on Rituximab and 6 cycles of Cytoxan infusion. She responded to Bortezomib therapy within 2 weeks of initiation, and with long-term sustenance of improvement in the long-term, also demonstrated by an improvement in NMDA titers . As far as we know, this is the first report of use of Bortezomib therapy in a child with refractory NMDA-receptor encephalitis.
Details
- Title: Subtitle
- Refractory NMDA-receptor encephalitis in a teenager: A novel use of Bortezomib
- Creators
- Tuhina Govil-Dalela - Wayne State UniversityIshita Datta - Children's Hospital of MichiganMitchel Williams - Central Michigan University
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimmunology, Vol.355, p.577565
- DOI
- 10.1016/j.jneuroim.2021.577565
- PMID
- 33813318
- NLM abbreviation
- J Neuroimmunol
- ISSN
- 0165-5728
- eISSN
- 1872-8421
- Publisher
- Elsevier
- Number of pages
- 3
- Language
- English
- Date published
- 06/15/2021
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984961027602771
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