Refractory Pediatric Fibrostenotic Eosinophilic Esophagitis Treated With Dupilumab

Gopinathan Gangadharan Nambiar; Riad Rahhal; Benjamin P. Davis; Yiqin Xiong; Donna Cheung

doi:10.14309/crj.0000000000000887

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$Refractory Pediatric Fibrostenotic Eosinophilic Esophagitis Treated With Dupilumab$

Journal article

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Refractory Pediatric Fibrostenotic Eosinophilic Esophagitis Treated With Dupilumab

Gopinathan Gangadharan Nambiar, Riad Rahhal, Benjamin P. Davis, Yiqin Xiong and Donna Cheung

ACG case reports journal, Vol.9(11), e00887

11/11/2022

DOI: 10.14309/crj.0000000000000887

PMCID: PMC9663132

PMID: 36382335

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Abstract

Eosinophilic esophagitis (EoE) is a progressive inflammatory disease of the esophagus. Untreated or uncontrolled disease over time can lead to the development of fibrosis and formation of strictures. Once the patient develops strictures, it is difficult to treat with the available medical therapies and will often require esophageal dilations. The Food and Drug Administration recently approved dupilumab for the treatment of EoE in patients older than 12 years. The clinical trials excluded patients with esophageal strictures. We describe a case of EoE with fibrostenotic stricture who had stricture resolution while on dupilumab therapy.

Esophagus

Case Report

Details

Title: Subtitle: Refractory Pediatric Fibrostenotic Eosinophilic Esophagitis Treated With Dupilumab
Creators: Gopinathan Gangadharan Nambiar - Division of Pediatric Gastroenterology, Hepatology, Pancreatology and Nutrition, University of Iowa Stead Family Children's Hospital, University of Iowa, Iowa City, IA Department of Pediatrics, East Tennessee State University, Johnson City, TN
Riad Rahhal - Division of Pediatric Gastroenterology, Hepatology, Pancreatology and Nutrition, University of Iowa Stead Family Children's Hospital, University of Iowa, Iowa City, IA
Benjamin P. Davis - Division of Allergy and Immunology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, IA
Yiqin Xiong - Department of Pathology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, IA
Donna Cheung - Division of Pediatric Gastroenterology, Hepatology, Pancreatology and Nutrition, University of Iowa Stead Family Children's Hospital, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: ACG case reports journal, Vol.9(11), e00887
DOI: 10.14309/crj.0000000000000887
PMID: 36382335
PMCID: PMC9663132
NLM abbreviation: ACG Case Rep J
eISSN: 2326-3253
Publisher: Wolters Kluwer
Language: English
Date published: 11/11/2022
Academic Unit: Stead Family Department of Pediatrics; Pathology; Gastroenterology, Hepatology, Pancreatology, and Nutrition; Immunology; Internal Medicine
Record Identifier: 9984315740702771

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