Logo image
Regenerating retinal fibers display error-free homing along undamaged normal fibers
Journal article   Peer reviewed

Regenerating retinal fibers display error-free homing along undamaged normal fibers

Claudia Wilm and Bernd Fritzsch
Journal of neurobiology, Vol.24(7), pp.898-902
07/1993
DOI: 10.1002/neu.480240703
PMID: 8228967

View Online

Abstract

After crushing one optic nerve in a bony fish, retinal fibers regenerate to both tecta. Anterograde labelling indicates that the ipsilaterally regenerating fibers have a rather straight growth, apparently along the undamaged fibers of the contralateral retina. In contrast, the contralaterally regenerating fibers deviate widely from a straight course. Retrograde labelling shows a mirror-symmetric distribution of regenerated ipsilateral and resident contralateral ganglion cells in a comparable annulus. In contrast, ganglion cells in the regenerated contralateral retina show no topological order after comparable small Dil applications to the ventrolateral tectum. These data suggest that regenerating fibers can orient on the undisturbed, contralateral fibers.
regeneration optic nerve topology of retinal projection guidance of regenerating fibers

Details

Metrics

Logo image