Journal article
Regional Aneurysm Wall Enhancement is Affected by Local Hemodynamics: A 7T MRI Study
American journal of neuroradiology : AJNR, Vol.42(3), pp.464-470
03/2021
DOI: 10.3174/ajnr.A6927
PMCID: PMC7959446
PMID: 33361379
Abstract
Aneurysm wall enhancement has been proposed as a biomarker for inflammation and instability. However, the mechanisms of aneurysm wall enhancement remain unclear. We used 7T MR imaging to determine the effect of flow in different regions of the wall.
Twenty-three intracranial aneurysms imaged with 7T MR imaging and 3D angiography were studied with computational fluid dynamics. Local flow conditions were compared between aneurysm wall enhancement and nonenhanced regions. Aneurysm wall enhancement regions were subdivided according to their location on the aneurysm and relative to the inflow and were further compared.
On average, wall shear stress was lower in enhanced than in nonenhanced regions (
= .05). Aneurysm wall enhancement regions at the neck had higher wall shear stress gradients (
= .05) with lower oscillations (
= .05) than nonenhanced regions. In contrast, aneurysm wall enhancement regions at the aneurysm body had lower wall shear stress (
= .01) and wall shear stress gradients (
= .008) than nonenhanced regions. Aneurysm wall enhancement regions far from the inflow had lower wall shear stress (
= .006) than nonenhanced regions, while aneurysm wall enhancement regions close to the inflow tended to have higher wall shear stress than the nonenhanced regions, but this association was not significant.
Aneurysm wall enhancement regions tend to have lower wall shear stress than nonenhanced regions of the same aneurysm. Moreover, the association between flow conditions and aneurysm wall enhancement seems to depend on the location of the region on the aneurysm sac. Regions at the neck and close to the inflow tend to be exposed to higher wall shear stress and wall shear stress gradients. Regions at the body, dome, or far from the inflow tend to be exposed to uniformly low wall shear stress and have more aneurysm wall enhancement.
Details
- Title: Subtitle
- Regional Aneurysm Wall Enhancement is Affected by Local Hemodynamics: A 7T MRI Study
- Creators
- S Hadad - From the Departments of Bioengineering and Mechanical Engineering (S.H., F.M., J.R.C.), George Mason University, Fairfax, Virginia shadad@gmu.eduF Mut - From the Departments of Bioengineering and Mechanical Engineering (S.H., F.M., J.R.C.), George Mason University, Fairfax, VirginiaB J Chung - Department of Applied Mathematics and Statistics (B.J.C.), Mountclair State University, Mountclair, New JerseyJ A Roa - Departments of Neurology, Neurosurgery, and Radiology (J.A.R., E.A.S.)A M Robertson - Department of Mechanical Engineering and Material Science (A.M.R.), University of Pittsburgh, Pittsburgh, PennsylvaniaD M Hasan - Neurosurgery (D.M.H.), University of Iowa, Iowa City, IowaE A Samaniego - Departments of Neurology, Neurosurgery, and Radiology (J.A.R., E.A.S.)J R Cebral - From the Departments of Bioengineering and Mechanical Engineering (S.H., F.M., J.R.C.), George Mason University, Fairfax, Virginia
- Resource Type
- Journal article
- Publication Details
- American journal of neuroradiology : AJNR, Vol.42(3), pp.464-470
- DOI
- 10.3174/ajnr.A6927
- PMID
- 33361379
- PMCID
- PMC7959446
- NLM abbreviation
- AJNR Am J Neuroradiol
- ISSN
- 0195-6108
- eISSN
- 1936-959X
- Publisher
- United States
- Grant note
- R01 NS097457 / NINDS NIH HHS S10 RR028821 / NCRR NIH HHS
- Language
- English
- Date published
- 03/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984070280602771
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