Journal article
Regional Blood-to-Tissue Transport in an Irradiated Rat Glioma Model
Radiation research, Vol.111(2), pp.225-236
08/1987
DOI: 10.2307/3576981
PMID: 3628713
Abstract
To assess vascular permeability in intracerebral grafts of the 36B-10, F-344 rat glioma following 20 Gy 137Cs whole brain irradiation, the blood-to-tissue transport constant, K, of [14C]-alpha-aminoisobutyric acid (AIB) was measured with quantitative autoradiography. Mean, 90th percentile, and 95th percentile values of K were determined in individual tumors and in treatment groups. In 15-day-old unirradiated control tumors, mean, 90th percentile, and 95th percentile values of K were, respectively, 11.3, 18.4, and 20.8 ml kg-1 min-1. In 15-day-old tumors irradiated on Day 14 (Day 1 postirradiation tumors) the K values were 5.9, 9.4, and 10.4, all of which were significantly less than the respective control values (P less than 0.01). In 16-day-old tumors irradiated on Day 14 (Day 2 postirradiation tumors), the K values were 10.8, 15.0, and 16.0, respectively, none of which was significantly different from control tumors. Mean K values for Day 2 vs Day 1 postirradiation tumors (10.8 vs 5.9) yielded P less than 0.05, but the 90th percentile and 95th percentile values for Day 2 vs Day 1 yielded 0.05 less than P less than 0.10. Separate experiments measured AIB and 86RbCl uptake in 36B-10 cells in vitro 1 and 2 days following 20 Gy irradiation to assess whether this radiation dose reduced the capacity of tumor cells to trap AIB or Rb+. Irradiation did not reduce the accumulation of either tracer, but rather was associated with an increased accumulation of AIB. Therefore, the AIB transport data suggest that vascular permeability and/or surface area decreases significantly in the day following 20 Gy irradiation and that this decrease reverses by the second day following irradiation.
Details
- Title: Subtitle
- Regional Blood-to-Tissue Transport in an Irradiated Rat Glioma Model
- Creators
- Alexander M SpenceMichael M GrahamLouise A O'GormanMark MuziGregory L AbbottThomas K Lewellen
- Resource Type
- Journal article
- Publication Details
- Radiation research, Vol.111(2), pp.225-236
- DOI
- 10.2307/3576981
- PMID
- 3628713
- ISSN
- 0033-7587
- eISSN
- 1938-5404
- Language
- English
- Date published
- 08/1987
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047793002771
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