Journal article
Regional Myocardial Remodeling Characteristics Correlates With Cardiac Events in Sarcoidosis
Journal of magnetic resonance imaging, Vol.52(2), pp.499-509
08/2020
DOI: 10.1002/jmri.27057
PMID: 31950573
Abstract
The poor prognosis of cardiac sarcoidosis (CS) underscores the need for risk stratification.
To investigate the prognostic significance of ventricular/myocardial remodeling features in sarcoidosis.
Retrospective.
In all, 132 biopsy-proven sarcoidosis patients imaged from 2008 to 2018. The primary endpoint was a composite of cardiac mortality, new onset arrhythmias, hospitalization for heart failure, and device implantation.
No field strength or sequence restrictions.
Global and regional ventricular/myocardial remodeling features were assessed by standard volumetric measurements and automated function imaging postprocessing analysis.
Student's t-test or Mann-Whitney test (chi
test or Fisher's exact test for categorical variables) were used for comparisons. Cox-proportional hazards regression model, univariate /multivariate analyses, and receiver operating characteristic were performed to relate clinical/lab data, imaging parameters to the endpoints.
Over a median follow-up of 40.7 (interquartile range 18.8-60.5) months, 41 (31.1%) patients developed adverse cardiac events. Abnormal left ventricular (LV) geometric remodeling alterations (measured by LV mass index and relative wall thickness) occurred 3.66-fold more frequently in patients with endpoints than patients without. The ratio of patients with endpoints increased as ventricular remodeling phenotype progressed. In patients with endpoints, regional myocardial wall thickness (RMWT) was significantly (P = 0.022) increased in six clustered LV segments located in the middle interventricular septum and basal/middle anterolateral walls. In all of the abnormal ventricular remodeling stages, patients with endpoints constantly had higher mean RMWT than those without. Among clinical, electrocardiographic, and imaging parameters, LV mass index (hazard ratio [HR] 1.010 95% confidence interval [CI] 1.002-1.018, P = 0.017) and mean RMWT (HR 3.482 95% CI 1.679-7.223, P = 0.001) were independently associated with endpoints. Sarcoidosis patients without this RMWT distribution pattern were significantly (P < 0.001) more likely to be free of the occurrence of subsequent cardiac events.
Regional myocardial remodeling characteristics are associated with subsequent adverse cardiac events in sarcoidosis.
3 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:499-509.
Details
- Title: Subtitle
- Regional Myocardial Remodeling Characteristics Correlates With Cardiac Events in Sarcoidosis
- Creators
- Chenying Lu - SUNY Upstate Medical UniversityJian Chen - Fifth Affiliated Hospital of Sun Yat-sen UniversityPromporn Suksaranjit - University of IowaYusuf Menda - University of IowaMehul Adhaduk - University of IowaManju B Jayanna - University of IowaErnest Scalzetti - SUNY Upstate Medical UniversityJiansong Ji - Lishui UniversityTiemin Wei - Lishui UniversityDavid Feiglin - SUNY Upstate Medical UniversityKan Liu - SUNY Upstate Medical University
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.52(2), pp.499-509
- DOI
- 10.1002/jmri.27057
- PMID
- 31950573
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Language
- English
- Date published
- 08/2020
- Academic Unit
- Radiology; Cardiovascular Medicine; Radiation Oncology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984313092902771
Metrics
14 Record Views