Journal article
Regional assignment of the gene for human liver/bone/kidney alkaline phosphatase to chromosome 1p36.1–p34
Genomics (San Diego, Calif.), Vol.2(2), pp.139-143
1988
DOI: 10.1016/0888-7543(88)90095-X
PMID: 3410475
Abstract
We have used three different methods to map the human liver/bone/kidney alkaline phosphatase (ALPL) locus: (1) Southern blot analysis of DNA derived from a panel of human-rodent somatic cell hybrids; (2)
in situ hybridization to human chromosomes; and (3) genetic linkage analysis. Our results indicate that the ALPL locus maps to human chromosome bands 1p36.1-p34 and is genetically linked to the Rh (maximum lod score of 15.66 at a recombination value of 0.10) and fucosidase A (maximum lod score of 8.24 at a recombination value of 0.02) loci. These results, combined with restriction fragment length polymorphisms identified by ALPL DNA probes, provide a useful marker for gene mapping studies involving the short arm of chromosome 1. In addition, our results help to elucidate further the structure and evolution of the human alkaline phosphatase multigene enzyme family.
Details
- Title: Subtitle
- Regional assignment of the gene for human liver/bone/kidney alkaline phosphatase to chromosome 1p36.1–p34
- Creators
- Moyra Smith - Department of Pediatrics, University of California, Irvine, California 92715 USAMitchell J Weiss - Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USAConstance A Griffin - Children's Hospital of Philadelphia, Department of Pediatrics, Philadelphia, Pennsylvania 19104 USAJeffrey C Murray - Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242 USAKenneth H Buetow - Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 USABeverly S Emanuel - Children's Hospital of Philadelphia, Department of Pediatrics, Philadelphia, Pennsylvania 19104 USAPaula S Henthorn - Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USAHarry Harris - Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.2(2), pp.139-143
- DOI
- 10.1016/0888-7543(88)90095-X
- PMID
- 3410475
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1988
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025559702771
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