Regional atrophy associated with cognitive and motor function in prodromal Huntington disease

Elizabeth H Aylward; Deborah L Harrington; James A Mills; Peggy C Nopoulos; Christopher A Ross; Jeffrey D Long; Dawei Liu; Holly K Westervelt; Jane S Paulsen; PREDICT-HD Investigators and Coordinators of the Huntington Study Group

doi:10.3233/JHD-130076

Back

Regional atrophy associated with cognitive and motor function in prodromal Huntington disease

Journal article

Peer reviewed

Regional atrophy associated with cognitive and motor function in prodromal Huntington disease

Elizabeth H Aylward, Deborah L Harrington, James A Mills, Peggy C Nopoulos, Christopher A Ross, Jeffrey D Long, Dawei Liu, Holly K Westervelt, Jane S Paulsen and PREDICT-HD Investigators and Coordinators of the Huntington Study Group

Journal of Huntington's disease, Vol.2(4), pp.477-489

2013

DOI: 10.3233/JHD-130076

PMCID: PMC4412155

PMID: 25062732

Files and links (1)

url

http://doi.org/10.3233/JHD-130076View

Open Access

Abstract

Neuroimaging studies suggest that volumetric MRI measures of specific brain structures may serve as excellent biomarkers in future clinical trials of Huntington disease (HD). Demonstration of the clinical significance of these measures is an important step in determining their appropriateness as potential outcome measures. Measures of gray- and white-matter lobular volumes and subcortical volumes (caudate, putamen, globus pallidus, thalamus, nucleus accumbens, hippocampus) were obtained from MRI scans of 516 individuals who tested positive for the HD gene expansion, but were not yet exhibiting signs or symptoms severe enough to warrant diagnosis ("pre-HD"). MRI volumes (corrected for intracranial volume) were correlated with cognitive, motor, psychiatric, and functional measures known to be sensitive to subtle changes in pre-HD. Caudate, putamen, and globus pallidus volumes consistently correlated with cognitive and motor, but not psychiatric or functional measures in pre-HD. Volumes of white matter, nucleus accumbens, and thalamus, but not cortical gray matter, also correlated with some of the motor and cognitive measures. Results of regression analyses suggest that volumes of basal ganglia structures contributed more highly to the prediction of most motor and cognitive variables than volumes of other brain regions. These results support the use of volumetric measures, especially of the basal ganglia, as outcome measures in future clinical trials in pre-HD. Results may also assist investigators in selecting the most appropriate measures for treatment trials that target specific clinical features or regions of neuropathology.

Magnetic Resonance Imaging

Psychomotor Performance

Humans

Huntington Disease - pathology

Atrophy - pathology

Cognition Disorders - pathology

Image Interpretation, Computer-Assisted

Male

Cognition

Prodromal Symptoms

Huntington Disease - complications

Neuropsychological Tests

Cognition Disorders - etiology

Brain - pathology

Adult

Female

Details

Title: Subtitle: Regional atrophy associated with cognitive and motor function in prodromal Huntington disease
Creators: Elizabeth H Aylward - Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA
Deborah L Harrington - Department of Radiology, University of California, San Diego, La Jolla, CA, USA VA San Diego Healthcare System, Research Service, San Diego, CA, USA
James A Mills - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
Peggy C Nopoulos - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
Christopher A Ross - Departments of Psychiatry, Neurology and Neuroscience, Johns Hopkins University, Baltimore, MD, USA
Jeffrey D Long - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
Dawei Liu - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
Holly K Westervelt - Division of Biology and Medicine, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
Jane S Paulsen - Departments of Psychiatry, Neurology, Psychology and Neuroscience, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Contributors: Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
Resource Type: Journal article
Publication Details: Journal of Huntington's disease, Vol.2(4), pp.477-489
DOI: 10.3233/JHD-130076
PMID: 25062732
PMCID: PMC4412155
NLM abbreviation: J Huntingtons Dis
ISSN: 1879-6397
eISSN: 1879-6400
Publisher: Netherlands
Grant note: 1U01NS082085 / NINDS NIH HHS R01 NS040068 / NINDS NIH HHS U01 NS082085 / NINDS NIH HHS R01 NS054893 / NINDS NIH HHS 1U01NS082086 / NINDS NIH HHS 2 UL1 TR000442-06 / NCATS NIH HHS 5R01NS054893 / NINDS NIH HHS UL1 TR000442 / NCATS NIH HHS PD30 HD02274 / NICHD NIH HHS 1U01NS082083 / NINDS NIH HHS 5R01NS040068 / NINDS NIH HHS P30 HD002274 / NICHD NIH HHS U01 NS082083 / NINDS NIH HHS U01 NS082086 / NINDS NIH HHS
Language: English
Date published: 2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
Record Identifier: 9984070857202771

Metrics

36 Record Views

53 Times Cited - Web of Science