Regional differences of [(18)F]-FDG uptake within the brain during fatiguing muscle contractions

John H Kindred; Kari K Kalliokoski; Jens Bojsen-Møller; Thorsten Rudroff

doi:10.1002/brb3.319

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Regional differences of [(18)F]-FDG uptake within the brain during fatiguing muscle contractions

Journal article

Open access

Peer reviewed

Regional differences of [(18)F]-FDG uptake within the brain during fatiguing muscle contractions

John H Kindred, Kari K Kalliokoski, Jens Bojsen-Møller and Thorsten Rudroff

Brain and behavior, Vol.5(4), pp.e00319-n/a

04/2015

DOI: 10.1002/brb3.319

PMCID: PMC4356841

PMID: 25798334

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Abstract

Many studies have shown that a position task is more difficult than a force task although both are performed at a similar net muscle force. Thus, the time to task failure is consistently shown to be briefer during the position task. The contributions of the central nervous system to these two types of fatiguing contractions are not completely understood. The purpose of this pilot study was to examine differences in regional brain activity between force and position tasks using positron emission tomography (PET) with [(18)F]-Fluorodeoxyglucose (FDG). Two participants performed both a force and position task, separated by 7 days, with the elbow flexor muscles at 15% maximal voluntary contraction force. During both tasks, each participant was injected with ≈ 256 (SD 11) MBq of FDG. Immediately after both tasks PET imaging was performed and images were analyzed to determine FDG uptake within regions of the brain. FDG uptake was greater in the occipital and temporal cortices of the brain during the position task compared to the force task. These findings suggest that differences in visual-spatial feedback and processing may play a role in the reduced time to failure of position tasks. Future application of these findings may lead to improved designs of rehabilitative strategies involving different types of visual feedback.

Humans

Middle Aged

Male

Brain Mapping - methods

Muscle, Skeletal - physiology

Positron-Emission Tomography - methods

Brain - physiology

Pilot Projects

Muscle Contraction - physiology

Adult

Fluorodeoxyglucose F18

Muscle Fatigue - physiology

Radiopharmaceuticals

Details

Title: Subtitle: Regional differences of [(18)F]-FDG uptake within the brain during fatiguing muscle contractions
Creators: John H Kindred - Department of Health and Exercise Science, Colorado State University Fort Collins, Colorado
Kari K Kalliokoski - Turku PET Centre, University of Turku and Turku University Hospital Turku, Finland
Jens Bojsen-Møller - Department of Physical Performance, Norwegian School of Sport Sciences Oslo, Norway
Thorsten Rudroff - Department of Health and Exercise Science, Colorado State University Fort Collins, Colorado
Resource Type: Journal article
Publication Details: Brain and behavior, Vol.5(4), pp.e00319-n/a
DOI: 10.1002/brb3.319
PMID: 25798334
PMCID: PMC4356841
NLM abbreviation: Brain Behav
ISSN: 2162-3279
eISSN: 2162-3279
Publisher: United States
Language: English
Date published: 04/2015
Academic Unit: Neurology; Health, Sport, and Human Physiology
Record Identifier: 9984002467702771

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