Journal article
Regional hypoxic pulmonary vasoconstriction in dogs with asymptomatic dirofilariasis
American journal of veterinary research, Vol.46(6), pp.1341-1345
06/1985
PMID: 4026011
Abstract
The pulmonary hemodynamic response to unilateral alveolar hypoxia was investigated in pentobarbital-anesthetized dogs with mild heartworm (HW) disease and in dogs free of HW (HWF). Left lung nitrogen ventilation in HWF dogs resulted in a decrease in the fraction of the cardiac output (QT) perfusing the left lung (QL) from 0.37 +/- 0.03 (SEM) to 0.20 +/- 0.02 (P less than 0.01). In contrast, dogs with mild HW disease did not develop a significant decrease in QL/QT which decreased from 0.38 +/- 0.02 to 0.33 +/- 0.02. This attenuated pulmonary vascular response to regional alveolar hypoxia in dogs with HW disease was associated with a normal pulmonary arterial pressure (14.8 +/- 1.5 mm of Hg) that was not different from that seen in HWF dogs (15.8 +/- 1.7 mm of Hg). These results indicate that mild HW disease interferes with the ability of hypoxic pulmonary vasoconstriction to redistribute pulmonary blood flow away from hypoxic regions of the lung.
Details
- Title: Subtitle
- Regional hypoxic pulmonary vasoconstriction in dogs with asymptomatic dirofilariasis
- Creators
- M W ChapleauR E FishM G Levitzky
- Resource Type
- Journal article
- Publication Details
- American journal of veterinary research, Vol.46(6), pp.1341-1345
- Publisher
- United States
- PMID
- 4026011
- ISSN
- 0002-9645
- eISSN
- 1943-5681
- Grant note
- HL 29042 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/1985
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025580502771
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