Journal article
Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with Type 2 diabetes
Journal of endocrinological investigation, Vol.36(2), pp.111-117
02/2013
DOI: 10.3275/8333
PMCID: PMC4457376
PMID: 22522495
Abstract
Background: Aging is associated with a decline in skeletal muscle size.Muscle is critical both for mobility and glucose disposal. While resistance exercise (RE) increases muscle mass and function in the elderly, its role in improving glucose utilization is less clear. Aims: To investigate whether muscle size was linked with insulin sensitivity (IS) in elders with diabetes following RE and if regional muscle glucose uptake differed from systemic glucose utilization. Methods: Seven (68.4±5.9 yr) adults with diabetes participated. After 16 weeks of RE, within 24 h (post 1) and after 1 week of no exercise (post 2), lean tissue cross-sectional area (CSA) and IS via glucose infusion rate (GIR) were assessed along with a standardized 18-F fluorodeoxyglucose (FDG)-positron emission tomography uptake value (SUV). Results: CSA increased between pre-test (108.5±35.3 cm2) and post 1 (116.8±40.9 cm2), p=0.02 and did not differ at post 2 (116.0±39.3 cm2). GIR during the 40 mU/m2/min insulin clamp differed between pretest (22.0±15.8 mg/kg/min) and post 1 (67.9±72.8 mg/kg/min), and post 1 and post 2 (25.0±27.2 mg/kg/min) but not between pre-test and post 2. GIR results during the 200 mU/m2/min insulin clamps also differed between pre-test and post 1, and post 1 and post 2 but not between pre-test and post 2. FDG-SUV increased between pre-test (1.1±0.2) and post 1 (1.4±0.3), and remained stable between post 1 and post 2 (1.4±0.4). Conclusion: RE that increased muscle size and FDG-SUV improved IS 24 h but not 1 week after exercise training.
Details
- Title: Subtitle
- Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with Type 2 diabetes
- Creators
- R.L Marcus - Department of Physical Therapy, University of Utah, Salt Lake City, Utah, United States of AmericaO Addison - Department of Physical Therapy, University of Utah, Salt Lake City, Utah, United States of AmericaP.C LaStayo - Department of Physical Therapy, University of Utah, Salt Lake City, Utah, United States of AmericaR Hungerford - Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, United States of AmericaA.R Wende - Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, United States of AmericaJ.M Hoffman - Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah, United States of AmericaE.D Abel - Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, United States of AmericaD.A McClain - Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
- Resource Type
- Journal article
- Publication Details
- Journal of endocrinological investigation, Vol.36(2), pp.111-117
- DOI
- 10.3275/8333
- PMID
- 22522495
- PMCID
- PMC4457376
- ISSN
- 0391-4097
- eISSN
- 1720-8386
- Language
- English
- Date published
- 02/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024545402771
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