Journal article
Regional pulmonary blood flow in dogs by 4D-X-ray CT
Journal of applied physiology (1985), Vol.101(5), pp.1451-1465
2006
DOI: 10.1152/japplphysiol.01131.2005
PMID: 16825517
Abstract
ECG-triggered computed tomography (CT) was used during passage of iodinated contrast to determine regional pulmonary blood flow (PBF) in anesthetized prone/supine dogs. PBF was evaluated as a function of height within the lung (supine and prone) as a function of various normalization methods: raw unit volume data (PBFraw) or PBF normalized to regional fraction air (PBFair), fractional non-air (PBFgm), or relative number of alveoli (PBFalv). The coefficient of variation of PBFraw, PBFair, PBFalv, and PBFgm ranged between 30 and 50% in both lungs and both body postures. The position of maximal flow along the height of the lung (MFP) was calculated for PBFraw, PBFair, PBFalv, and PBFgm. Only PBFgm showed a significantly different MFP height supine vs. prone (whole lung: 2.60 ± 1.08 cm supine vs. 5.08 ± 1.61 cm prone, P < 0.01). Mean slopes (ml/min/gm water content/cm) of PBFgm were steeper supine vs. prone in the right (RL) but not left lung (LL) (RL: −0.65 ± 0.29 supine vs. −0.26 ± 0.25 prone, P < 0.02; LL: −0.47 ± 0.21 supine vs. −0.32 ± 0.26 prone, P > 0.10). Mean slopes of PBFgm vs. vertical lung height were not different prone vs. supine above this vertical height of MFP (VMFP), but PBFgm slopes were steeper in the supine position below the VMFP in the RL. We conclude that PBFgm distribution was posture dependent in RL but not LL. Support of the heart may play a role. We demonstrate that normalization factors can lead to differing attributions of gravitational effects on PBF heterogeneity.
Details
- Title: Subtitle
- Regional pulmonary blood flow in dogs by 4D-X-ray CT
- Creators
- Deokiee CHON - Department of Radiology, University of Iowa, Iowa City, Iowa, United StatesKenneth C BECK - Department of Radiology, University of Iowa, Iowa City, Iowa, United StatesRanae L LARSEN - Departments of Medicine, Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United StatesHidenori SHIKATA - Department of Radiology, University of Iowa, Iowa City, Iowa, United StatesEric A HOFFMAN - Department of Radiology, University of Iowa, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.101(5), pp.1451-1465
- Publisher
- American Physiological Society; Bethesda, MD
- DOI
- 10.1152/japplphysiol.01131.2005
- PMID
- 16825517
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051747102771
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