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Regional vascular effects of vasopressin: plasma levels and circulatory responses
Journal article   Peer reviewed

Regional vascular effects of vasopressin: plasma levels and circulatory responses

Phillip G Schmid, Francois Abboud, Michael G Wendling, Eric S Ramberg, Allyn L Mark, Donald D Heistad and John W Eckstein
The American journal of physiology, Vol.227(5), pp.998-1004
11/1974
DOI: 10.1152/ajplegacy.1974.227.5.998
PMID: 4440765

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Abstract

In this investigation of the relationship of plasma concentrations (bioassay) and vasoconstrictor effects of vasopressin, gracilis muscle was most sensitive, responding to an increase of 28 μU vasopressin per ml of plasma (base line 50±13 μU/ml, mean±SE, n=5). In other dogs, increases averaging 49 μU/ml (base line 66±8 μU/ml, n=6) caused significant increases in renal but not mesenteric and iliac blood flows, indicating redistribution of cardiac output to kidney from other beds to constrictor effects of vasopressin. Increases in vasopressin associated with significant vasoconstriction in the iliac bed were smaller (144 μU/ml) than those associated with significant vasoconstriction in mesentery (215 μU/ml); also intravenous infusions of vasopressin caused significant redistribution of cardiac output away from hindlimb, but not mesentery and kidney. Thus, the relative sensitivity of different vascular beds to constrictor effects of vasopressin would appear to be muscle > mesentery > kidney. These results suggest a role of vasopressin in circulatory regulation.
 Kidney - blood supply Cardiac Output - drug effects Vasomotor System - drug effects Vasopressins - pharmacology Male Regional Blood Flow Vasopressins - blood Skin - blood supply Heart Rate - drug effects Animals Hindlimb - blood supply Iliac Artery Dogs Mesenteric Arteries Vascular Resistance - drug effects Blood Pressure - drug effects Hemodynamics - drug effects Muscles - blood supply

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