Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling

Alix A J Rouault; Abigail A Lee; Julien A Sebag

doi:10.1016/j.bbamcr.2017.09.008

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Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling

Journal article

Open access

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Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling

Alix A J Rouault, Abigail A Lee and Julien A Sebag

Biochimica et biophysica acta. Molecular cell research, Vol.1864(12), pp.2322-2329

12/2017

DOI: 10.1016/j.bbamcr.2017.09.008

PMID: 28939058

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Abstract

The Melanocortin Receptor Accessory Protein 2 (MRAP2) regulates the activity of several GPCRs involved in the control of food intake and energy expenditure. While MRAP2 was originally thought to exclusively interact with melanocortin receptors we have recently shown that it interacts with and inhibits the trafficking and signaling of the prokineticin receptor 1 (PKR1). In this study we demonstrate a new role of MRAP2 in the regulation of the orexin receptor 1 (OX1R) and identify the specific regions of MRAP2 required for the regulation of OX1R and PKR1. Importantly, like MC4R and PKRs, OX1R is predominately expressed in the brain where it regulates food intake. By demonstrating that MRAP2 modulates the activity of OX1R we further establish the critical role of MRAP2 in the control of energy homeostasis.

Orexins - genetics

Cricetulus

Orexins - metabolism

Signal Transduction

Humans

Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - metabolism

Eating - genetics

Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - genetics

Carrier Proteins - genetics

Animals

Carrier Proteins - metabolism

Orexin Receptors - genetics

Receptors, G-Protein-Coupled - genetics

Calcium Signaling - genetics

Energy Metabolism - genetics

CHO Cells

Details

Title: Subtitle: Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling
Creators: Alix A J Rouault - Department of Molecular Physiology and Biophysics, Carver College of Medicine, Fraternal Order of Eagle Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa, Iowa City, United States
Abigail A Lee - Department of Molecular Physiology and Biophysics, Carver College of Medicine, Fraternal Order of Eagle Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa, Iowa City, United States
Julien A Sebag - Department of Molecular Physiology and Biophysics, Carver College of Medicine, Fraternal Order of Eagle Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa, Iowa City, United States. Electronic address: Julien-sebag@uiowa.edu
Resource Type: Journal article
Publication Details: Biochimica et biophysica acta. Molecular cell research, Vol.1864(12), pp.2322-2329
DOI: 10.1016/j.bbamcr.2017.09.008
PMID: 28939058
NLM abbreviation: Biochim Biophys Acta Mol Cell Res
ISSN: 0167-4889
eISSN: 1879-2596
Publisher: Netherlands
Grant note: name: Fraternal Order of Eagles Diabetes Research Center; name: Carver Trust Young Investigator Award
Language: English
Date published: 12/2017
Academic Unit: Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984070296802771

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