Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics

Sanghun Choi; Eric A Hoffman; Sally E Wenzel; Merryn H Tawhai; Youbing Yin; Mario Castro; Ching-Long Lin

doi:10.1152/japplphysiol.00113.2013

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Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics

Journal article

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Peer reviewed

Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics

Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Merryn H Tawhai, Youbing Yin, Mario Castro and Ching-Long Lin

Journal of applied physiology (1985), Vol.115(5), pp.730-742

09/01/2013

DOI: 10.1152/japplphysiol.00113.2013

PMCID: PMC3763069

PMID: 23743399

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Abstract

The purpose of this work was to explore the use of image registration-derived variables associated with computed tomographic (CT) imaging of the lung acquired at multiple volumes. As an evaluation of the utility of such an imaging approach, we explored two groups at the extremes of population ranging from normal subjects to severe asthmatics. A mass-preserving image registration technique was employed to match CT images at total lung capacity (TLC) and functional residual capacity (FRC) for assessment of regional air volume change and lung deformation between the two states. Fourteen normal subjects and thirty severe asthmatics were analyzed via image registration-derived metrics together with their pulmonary function test (PFT) and CT-based air-trapping. Relative to the normal group, the severely asthmatic group demonstrated reduced air volume change (consistent with air trapping) and more isotropic deformation in the basal lung regions while demonstrating increased air volume change associated with increased anisotropic deformation in the apical lung regions. These differences were found despite the fact that both PFT-derived TLC and FRC in the two groups were nearly 100% of predicted values. Data suggest that reduced basal-lung air volume change in severe asthmatics was compensated by increased apical-lung air volume change and that relative increase in apical-lung air volume change in severe asthmatics was accompanied by enhanced anisotropic deformation. These data suggest that CT-based deformation, assessed via inspiration vs. expiration scans, provides a tool for distinguishing differences in lung mechanics when applied to the extreme ends of a population range.

asthma

quantitative computed tomography

image registration

lung mechanics

air trapping

Details

Title: Subtitle: Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics
Creators: Sanghun Choi - Department of Mechanical and Industrial Engineering
Eric A Hoffman - Department of Biomedical Engineering
Sally E Wenzel - Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Merryn H Tawhai - Bioengineering Institute, University of Auckland, Auckland, New Zealand; and
Youbing Yin - Department of Mechanical and Industrial Engineering
Mario Castro - Departments of Internal Medicine and Pediatrics, Washington University School of Medicine, St. Louis, Missouri
Ching-Long Lin - Department of Mechanical and Industrial Engineering
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.115(5), pp.730-742
DOI: 10.1152/japplphysiol.00113.2013
PMID: 23743399
PMCID: PMC3763069
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: American Physiological Society; Bethesda, MD
Language: English
Date published: 09/01/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984051531802771

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