Journal article
Registration-based estimates of local lung tissue expansion compared to xenon-CT measures of specific ventilation
Medical image analysis, Vol.12(6), pp.752-763
12/2008
DOI: 10.1016/j.media.2008.03.007
PMCID: PMC2692217
PMID: 18501665
Abstract
The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation and regional specific volume change. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field, which we show is directly related to specific volume change. We compare the ventral-dorsal patterns of lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation in five anesthetized sheep studied in the supine orientation. Using 3D image registration to match images acquired at 10 cm H
2
O and 15 H
2
O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation (linear regression, average
r
2
= 0.73).
Details
- Title: Subtitle
- Registration-based estimates of local lung tissue expansion compared to xenon-CT measures of specific ventilation
- Creators
- Joseph M Reinhardt - University of IowaKai Ding - University of IowaKunlin Cao - University of IowaGary E Christensen - University of IowaEric A Hoffman - University of IowaShalmali V Bodas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Medical image analysis, Vol.12(6), pp.752-763
- DOI
- 10.1016/j.media.2008.03.007
- PMID
- 18501665
- PMCID
- PMC2692217
- NLM abbreviation
- Med Image Anal
- ISSN
- 1361-8415
- eISSN
- 1361-8423
- Language
- English
- Date published
- 12/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Radiation Oncology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center; Internal Medicine
- Record Identifier
- 9984197006802771
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