Journal article
Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
Clinical science (1979), Vol.124(5-6), pp.325-331
03/01/2013
DOI: 10.1042/CS20120291
PMCID: PMC3509933
PMID: 23025811
Abstract
In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular aerobic exercise prevents this effect. Data were analysed from a cohort of 131 non-smoking men and women without overt clinical disease. Compared with young adult controls (age = 24 +/- 1 years, n = 29; values are means +/- S.E.M.), brachial artery FMD (flow-mediated dilation), a measure of conduit artery EDD (endothelium-dependent dilation), was 33% lower [7.93 +/- 0.33 against 5.27 +/- 0.37%Delta (% change), P < 0.05] in MA/O (middle-aged/older) adults with NFG (normal fasting plasma glucose) (<= 99 mg/dl, 62 +/- 1 years, n = 35). In MA/O adults with IFG (100-125 mg/dl, 64 +/- 1 years, n = 28), FMD was 30% lower (3.37 +/- 0.35%Delta) than in their peers with NFG and 58% lower than young controls (P < 0.05). Brachial artery FMD was greater (6.38 +/- 0.35%Delta) in MA/O adults with NFG who regularly performed aerobic exercise (>45 min/day for >= 5 days/week, 62 +/- 1 years, n = 23) compared with their non-exercising peers and only slightly less than young controls (P < 0.05). Most importantly, FMD was completely preserved in MA/O adults with IFG who regularly performed aerobic exercise (6.99 +/- 0.69%Delta, 65 +/- 1 years, n = 16). In the pooled sample, fasting plasma glucose was inversely related to FMD (r = -0.42, P < 0.01) and was the strongest independent predictor of FMD (R-2=0.32). Group differences in FMD were not affected by other subject characteristics or brachial artery properties, including brachial artery dilation to sublingual NTG (nitroglycerine, i.e. endothelium-independent dilation). IFG exacerbates age-associated vascular endothelial dysfunction and this adverse effect is completely prevented in MA/O adults who regularly perform aerobic exercise.
Details
- Title: Subtitle
- Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
- Creators
- Allison E. DeVan - University of Colorado BoulderIratxe Eskurza - University of Colorado BoulderGary L. Pierce - University of Colorado BoulderAshley E. Walker - University of Colorado BoulderKristen L. Jablonski - University of Colorado BoulderRachelle E. Kaplon - University of Colorado BoulderDouglas R. Seals - University of Colorado Boulder
- Resource Type
- Journal article
- Publication Details
- Clinical science (1979), Vol.124(5-6), pp.325-331
- DOI
- 10.1042/CS20120291
- PMID
- 23025811
- PMCID
- PMC3509933
- NLM abbreviation
- Clin Sci (Lond)
- ISSN
- 0143-5221
- eISSN
- 1470-8736
- Publisher
- Portland Press Ltd
- Number of pages
- 7
- Grant note
- UL1TR001082 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) 0715735Z / American Heart Association P30DK048520 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) AG013038; AG000279; AG033994; AG031617; RR00051; TR000154 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA F31AG031617 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 03/01/2013
- Academic Unit
- Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984267245102771
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