Regularized Joint Reconstruction and Slab Combination for Accelerated Three-Dimensional Multi-Slab Diffusion-Weighted Imaging Using Multi-Scale Energy Models

Reza Ghorbani; Jyothi Rikhab Chand; Chu-Yu Lee; Mathews Jacob; Merry Mani

doi:10.1002/mrm.70512

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Regularized Joint Reconstruction and Slab Combination for Accelerated Three-Dimensional Multi-Slab Diffusion-Weighted Imaging Using Multi-Scale Energy Models

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Regularized Joint Reconstruction and Slab Combination for Accelerated Three-Dimensional Multi-Slab Diffusion-Weighted Imaging Using Multi-Scale Energy Models

Reza Ghorbani, Jyothi Rikhab Chand, Chu-Yu Lee, Mathews Jacob and Merry Mani

Magnetic resonance in medicine

07/28/2026

DOI: 10.1002/mrm.70512

PMID: 42521420

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Abstract

To jointly reconstruct high-resolution diffusion-weighted volumes and eliminate slab-boundary artifacts while preserving fine anatomical detail from undersampled 3D multi-slab k-space acquisitions. A bilinear forward model was formulated to describe the 3D multi-slab acquisition, treating the image volume and slab excitation profiles as joint variables. A maximum a posteriori framework optimized a cost function with a Gaussian data-fidelity term, a CNN-based deep energy prior guiding accelerated recovery, and a quadratic regularization term anchoring the slab profiles to an initial estimate. The energy-based prior models the negative log distribution of clean diffusion-weighted images, while its gradient guides the accelerated reconstruction toward the artifact-free distribution. The resulting non-convex problem was solved via alternating minimization, where the image volume was updated through a majorize-minimize scheme with conjugate gradient optimization, and slab profiles were estimated through regularized least-squares optimization. The proposed Energy-based Profile Encoding (EPEN) framework substantially reduced slab-boundary artifacts compared with conventional slab-boundary correction approaches. Improved structural consistency and contrast preservation were achieved across multiple acceleration factors and slab configurations. EPEN enables robust joint 3D multi-slab diffusion MRI reconstruction with slab profile correction within an alternating optimization framework using deep energy-based image priors.

multi‐scale energy model

3D multi‐slab diffusion MRI

boundary artifact correction

Details

Title: Subtitle: Regularized Joint Reconstruction and Slab Combination for Accelerated Three-Dimensional Multi-Slab Diffusion-Weighted Imaging Using Multi-Scale Energy Models
Creators: Reza Ghorbani - University of Virginia
Jyothi Rikhab Chand - University of Virginia
Chu-Yu Lee - University of Iowa, Radiology
Mathews Jacob - University of Virginia
Merry Mani - University of Virginia Medical Center
Resource Type: Journal article
Publication Details: Magnetic resonance in medicine
DOI: 10.1002/mrm.70512
PMID: 42521420
ISSN: 0740-3194
eISSN: 1522-2594
Publisher: Wiley
Grant note: EB031169-02S1 / NIH HHS R01 EB031169 / NIH HHS 1S10RR028821-01 / NIBIB NIH HHS 1S10OD025025-01 / NIBIB NIH HHS 1S10OD030220-01 / NIBIB NIH HHS
Language: English
Electronic publication date: 07/28/2026
Academic Unit: Radiology; Electrical and Computer Engineering
Record Identifier: 9985217044202771

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