Regulation and function of IL-17A- and IL-22-producing γδ T cells

Kristin J Ness-Schwickerath; Craig T Morita

doi:10.1007/s00018-011-0700-z

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Regulation and function of IL-17A- and IL-22-producing γδ T cells

Journal article

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Regulation and function of IL-17A- and IL-22-producing γδ T cells

Kristin J Ness-Schwickerath and Craig T Morita

Cellular and molecular life sciences : CMLS, Vol.68(14), pp.2371-2390

07/2011

DOI: 10.1007/s00018-011-0700-z

PMCID: PMC3152582

PMID: 21573786

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Abstract

The regulation of IL-17A and IL-22 production differs between human and murine γδ T cells. We find that human γδ T cells expressing Vγ2Vδ2 T cell receptors are peripherally polarized to produce IL-17A or IL-22, much like CD4 αβ Th17 T cells. This requires IL-6, IL-1β, and TGF-β, whereas expansion and maintenance requires IL-23, IL-1β, and TGF-β. In contrast, IL-17A and IL-22 production by murine γδ T cells is innately programmed during thymic ontogeny but requires IL-23 and IL-1β for maintenance. Murine γδ cells producing IL-17A and IL-22 play important roles in microbial, autoimmune, and inflammatory responses. However, the roles played by human IL-17A- and IL-22-producing γδ T cells are less clear but are also likely to be important. These observations highlight differences between humans and murine γδ T cells and underscore the importance of IL-17A- and IL-22-producing γδ T cells.

Receptors, Antigen, T-Cell, gamma-delta - metabolism

Humans

Interleukin-17 - immunology

Receptors, Antigen, T-Cell, gamma-delta - immunology

Interleukins - metabolism

Interleukin-17 - metabolism

Models, Immunological

Animals

T-Lymphocytes - metabolism

Interleukins - immunology

T-Lymphocytes - immunology

Thymus Gland - immunology

Mice

Adaptive Immunity - immunology

Thymus Gland - metabolism

Details

Title: Subtitle: Regulation and function of IL-17A- and IL-22-producing γδ T cells
Creators: Kristin J Ness-Schwickerath - Division of Immunology, Department of Internal Medicine and the Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, EMRB 400F, Iowa City, IA 52242, USA
Craig T Morita
Resource Type: Journal article
Publication Details: Cellular and molecular life sciences : CMLS, Vol.68(14), pp.2371-2390
DOI: 10.1007/s00018-011-0700-z
PMID: 21573786
PMCID: PMC3152582
NLM abbreviation: Cell Mol Life Sci
ISSN: 1420-682X
eISSN: 1420-9071
Grant note: R01 AR045504-06 / NIAMS NIH HHS T32 AI007511 / NIAID NIH HHS R01 AR045504-10 / NIAMS NIH HHS AR045504 / NIAMS NIH HHS T32 AI007511-17 / NIAID NIH HHS R01 AR045504-07 / NIAMS NIH HHS R01 AR045504 / NIAMS NIH HHS R01 AR045504-09 / NIAMS NIH HHS R01 AR045504-11 / NIAMS NIH HHS R03 AR045095-04 / NIAMS NIH HHS R01 AR045504-08 / NIAMS NIH HHS
Language: English
Date published: 07/2011
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094578402771

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