Journal article
Regulation of Blood Flow to the Aortic Media in Dogs
The Journal of clinical investigation, Vol.62(1), pp.133-140
07/1978
DOI: 10.1172/JCI109097
PMCID: PMC371746
PMID: 659626
Abstract
Morphologic observations suggest that the inner layers of the thoracic aorta in man and dog are avascular and the outer layers have vasa vasorum. It appears that vasa vasorum are essential in the thoracic aorta because their interruption produces medial necrosis. These experiments provide the first measurements of blood flow through aortic vasa vasorum and examine physiologic regulation of that flow.\nDuring control conditions the outer two-thirds of the media of the thoracic aorta received 10 ml/min per 100 g blood flow through vasa vasorum. Flow to the inner third of the aorta was 1 ml/min per 100 g. Flow to both the inner and outer media of the abdominal aorta was less than 1 ml/min per 100 g. Adenosine increased blood flow to vasa vasorum in the outer media of the thoracic aorta from 7 to 18 ml/min per 100 g, but did not increase flow to the inner layers of the aorta. Hemorrhagic hypotension decreased flow in the outer media of the thoracic aorta from 14 to 2 ml/min per 100 g. Acute hypertension failed to increase blood flow through vasa vasorum, as conductance decreased significantly.\nThese studies indicate that vasa vasorum provide a considerable amount of blood flow to the outer layers of the thoracic aorta. The vessels are responsive to physiologic stimuli because they dilate during infusion of adenosine and constrict during both hemorrhagic hypotension and acute hypertension. We speculate that the failure of blood flow to the aortic wall to increase during acute hypertension might, if it were sustained, contribute to aortic medial necrosis.
Details
- Title: Subtitle
- Regulation of Blood Flow to the Aortic Media in Dogs
- Creators
- Donald D Heistad - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242Melvin L Marcus - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242Edward G Law - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242Mark L Armstrong - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242James C Ehrhardt - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242Francois M Abboud - Cardiovascular Division, Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.62(1), pp.133-140
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI109097
- PMID
- 659626
- PMCID
- PMC371746
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 07/1978
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025444402771
Metrics
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