Journal article
Regulation of C1- and K+ channels in airway epithelium
Annual review of physiology, Vol.52, pp.115-135
1990
DOI: 10.1146/annurev.ph.52.030190.000555
PMID: 2158763
Abstract
Stimulation of transepithelial Cl- secretion by the airway epithelium requires activation of channels at the two opposite sides of the cell: the apical and basolateral membranes. At the apical membrane, the Cl- channel is regulated by phosphorylation with PKA and PKC. At the basolateral membrane, the KCLIC channel is regulated by [Ca2+]c. Addition of a secretagogue that increases cellular levels of cAMP also causes release of Ca2+ from intracellular stores. The Ca2+ may then regulate basolateral membrane KCLIC channels. The cAMP-induced increase in [Ca2+]c and activation of the KCLIC channel is transient, however, whereas activation of the Cl- channel and stimulation of secretion is a more sustained response. Those results suggest that the presence of a second Ca2(+)-independent K+ channel located at the basolateral membrane, which is only expressed in cells grown on permeable supports.
Details
- Title: Subtitle
- Regulation of C1- and K+ channels in airway epithelium
- Creators
- J. D Mccann - University of IowaM. J Welsh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annual review of physiology, Vol.52, pp.115-135
- Publisher
- Annual Reviews
- DOI
- 10.1146/annurev.ph.52.030190.000555
- PMID
- 2158763
- ISSN
- 0066-4278
- eISSN
- 1545-1585
- Language
- English
- Date published
- 1990
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984259443802771
Metrics
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