Journal article
Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host
The Journal of immunology (1950), Vol.170(10), pp.4933-4942
05/15/2003
DOI: 10.4049/jimmunol.170.10.4933
PMID: 12734336
Abstract
Naive Ag-specific CD8(+) T cells expand, contract, and become memory cells after infection and/or vaccination. Memory CD8(+) T cells provide faster, more effective secondary responses against repeated exposure to the same pathogen. Using an adoptive transfer system with low numbers of trackable nontransgenic memory CD8(+) T cells, we showed that secondary responses can be comprised of both primary (naive) and secondary (memory) CD8(+) T cells after bacterial (Listeria monocytogenes) and/or viral (lymphocytic choriomeningitis virus) infections. The level of memory CD8(+) T cells present at the time of infection inversely correlated with the magnitude of primary CD8(+) T cell responses against the same epitope but directly correlated with the level of protection against infection. However, similar numbers of Ag-specific CD8(+) T cells were found 8 days postinfection no matter how many memory cells were present at the time of infection. Rapid contraction of primary CD8(+) T cell responses was not influenced by the presence of memory CD8(+) T cells. However, contraction of secondary CD8(+) T cell responses was markedly prolonged compared with primary responses in the same host mice. This situation occurred in response to lymphocytic choriomeningitis virus or L. monocytogenes infection and for CD8(+) T cell responses against multiple epitopes. The delayed contraction of secondary CD8(+) T cells was also observed after immunization with peptide-coated dendritic cells. Together, the results show that the level of memory CD8(+) T cells influences protective immunity and activation of naive precursors specific for the same epitope but has little impact on the magnitude or program of the CD8(+) T cell response.
Details
- Title: Subtitle
- Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host
- Creators
- Vladimir P Badovinac - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USAKelly A Nordyke MessinghamSara E HamiltonJohn T Harty
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.170(10), pp.4933-4942
- Publisher
- United States
- DOI
- 10.4049/jimmunol.170.10.4933
- PMID
- 12734336
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- AI42767 / NIAID NIH HHS AI46653 / NIAID NIH HHS AI50073 / NIAID NIH HHS
- Language
- English
- Date published
- 05/15/2003
- Academic Unit
- Dermatology; Microbiology and Immunology; Pathology
- Record Identifier
- 9984025560602771
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