Journal article
Regulation of Large Cerebral Arteries and Cerebral Microvascular Pressure
Circulation research, Vol.66(1), pp.8-17
01/1990
DOI: 10.1161/01.RES.66.1.8
PMID: 2403863
Abstract
Resistance of large arteries appears to be greater in the cerebral circulation than in other vascular beds. Large arteries contribute importantly to total cerebral vascular resistance and are major determinants of local microvascular pressure. Recent studies have shown that resistance of large arteries and cerebral microvascular pressure are affected by several physiological stimuli, including changes in systemic blood pressure, increases in cerebral metabolism, activity of sympathetic nerves, and humoral stimuli such as circulating vasopressin and angiotensin. Stimuli such as sympathetic stimulation and vasopressin produce selective responses of large arteries and, thereby, regulate microvascular pressure without a significant change in cerebral blood flow. These findings lead to the new hypothesis that the brain may be sensitive to changes in cerebral microvascular pressure, resulting in activation of compensatory neurohumoral mechanisms. Important changes occur in large cerebral arteries under pathophysiological conditions. Chronic hypertension increases resistance of large cerebral arteries, which protects the microcirculation against hypertension. Atherosclerosis potentiates constrictor responses of large cerebral arteries to serotonin and thromboxane, which may contribute to vasospasm and transient ischemic attacks.
Details
- Title: Subtitle
- Regulation of Large Cerebral Arteries and Cerebral Microvascular Pressure
- Creators
- Frank Faraci - Department of Internal Medicine and Pharmacology, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, IowaDonald Heistad
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.66(1), pp.8-17
- DOI
- 10.1161/01.RES.66.1.8
- PMID
- 2403863
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 01/1990
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040460902771
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